Mimicking Biological Membranes with Programmable Glycan Ligands Self-Assembled from Amphiphilic Janus Glycodendrimers (pages 10899–10903)
Dr. Shaodong Zhang, Dr. Ralph-Olivier Moussodia, Dr. Hao-Jan Sun, Dr. Pawaret Leowanawat, Adam Muncan, Christopher D. Nusbaum, Kathleen M. Chelling, Prof. Dr. Paul A. Heiney, Prof. Dr. Michael L. Klein, Priv.-Doz. Dr. Sabine André, Prof. Dr. René Roy, Prof. Dr. Hans-J. Gabius and Prof. Dr. Virgil Percec
Article first published online: 12 JUN 2014 | DOI: 10.1002/anie.201403186
Glycodendrimersomes: Amphiphilic Janus glycodendrimers with different topologies self-assemble into uniform unilamellar soft vesicles, denoted glycodendrimersomes, which are stable over time. They exhibit specific and potent bioactivity in binding biomedically relevant lectins. The vesicles with multivalent glycan ligands extending beyond their surface were shown to provide optimal glycan ligand display.