Angewandte Chemie International Edition

Cover image for Vol. 53 Issue 52

December 22, 2014

Volume 53, Issue 52

Pages 14275–14609

  1. Cover Pictures

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. You have free access to this content
      Cover Picture: Switching of Bacterial Adhesion to a Glycosylated Surface by Reversible Reorientation of the Carbohydrate Ligand (Angew. Chem. Int. Ed. 52/2014) (page 14275)

      Theresa Weber, Dr. Vijayanand Chandrasekaran, Insa Stamer, Prof. Dr. Mikkel B. Thygesen, Prof. Dr. Andreas Terfort and Prof. Dr. Thisbe K. Lindhorst

      Article first published online: 12 DEC 2014 | DOI: 10.1002/anie.201410966

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      The Yin and Yang of carbohydrate recognition: Bacteria (shown in green) have lectin-type appendages to adhere to glycosylated surfaces, such as the glycocalyx of host cells. In their Communication on page 14583 ff., A. Terfort, T. K. Lindhorst, and co-workers use a photoswitchable azobenzene glycoside monolayer as a glycocalyx model. The orientation of the carbohydrate ligands is controlled by photochemical E/Z isomerization of the azobenzene hinge. Thus, for bacterial cells, binding or not binding is a question of the orientation of the carbohydrate ligands.

    2. You have free access to this content
      Inside Cover: Green-Solvent-Processed Molecular Solar Cells (Angew. Chem. Int. Ed. 52/2014) (page 14276)

      Xiaofen Chen, Dr. Xiaofeng Liu, Mark A. Burgers, Dr. Ye Huang and Prof. Dr. Guillermo C. Bazan

      Article first published online: 4 DEC 2014 | DOI: 10.1002/anie.201411251

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      The careful choice of chemical structures allows the fabrication of high-performance molecular solar cells by solution deposition of molecular semiconductors from the green solvent 2-MeTHF. In their Communication on page 14378 ff., G. C. Bazan and co-workers demonstrate the relevance of these findings within the context of sustainability, the need to replace toxic substances for mass production, and the overall evaluation of various emerging photovoltaic technologies.

    3. You have free access to this content
      Inside Back Cover: Solvation Dynamics of a Single Water Molecule Probed by Infrared Spectra—Theory Meets Experiment (Angew. Chem. Int. Ed. 52/2014) (page 14611)

      Matthias Wohlgemuth, Dr. Mitsuhiko Miyazaki, Dr. Martin Weiler, Prof. Makoto Sakai, Prof. Otto Dopfer, Prof. Masaaki Fujii and Prof. Roland Mitrić

      Article first published online: 27 NOV 2014 | DOI: 10.1002/anie.201411161

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      Simulations of water solvation dynamics around biomolecular structures can be verified reliably by experimental time-resolved IR spectroscopy. In the work of a German–Japanese collaboration headed by O. Dopfer, M. Fujii, and R. Mitric and reported in a Communication on page 14601 ff., the approach was applied to the acetanilide–water cluster. Photoionization triggers the migration of a water molecule from the CO to the NH group of the amide by both a fast (red) and a slow (blue) reaction path.

    4. You have free access to this content
      Back Cover: Oxidative Metalation as a Route to Size-Mismatched Macrocyclic Complexes: Osmium Corroles (Angew. Chem. Int. Ed. 52/2014) (page 14612)

      Dr. Abraham B. Alemayehu, Dr. Kevin J. Gagnon, Prof. Dr. James Terner and Prof. Dr. Abhik Ghosh

      Article first published online: 4 DEC 2014 | DOI: 10.1002/anie.201411397

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      Heavy-element corroles are of great interest as optical sensors, near-IR dyes, phosphors, organic light-emitting diodes, and anticancer compounds, but the insertion of 5d metals into corroles is difficult. In their Communication on page 14411 ff., A. Ghosh and co-workers present the oxidative metalation of meso triarylcorroles with [Os3(CO)12]/NaN3 as a route to nitridoosmium(VI) corroles. These complexes exhibit distinctive domed folded macrocycles and multiple Os–nitrido stretching frequencies.

  2. Frontispiece

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. You have free access to this content
      Frontispiece: Intramolecular Metalloamination of N,N-Dimethylhydrazinoalkenes: A Versatile Method to Access Functionalized Piperidines and Pyrrolidines

      Bryce Sunsdahl, Adrian R. Smith and Prof. Dr. Tom Livinghouse

      Article first published online: 17 DEC 2014 | DOI: 10.1002/anie.201485261

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      Heterocycle Synthesis In their Communication on page 14352 ff., T. Livinghouse et al. describe the direct metalloamination/cyclization of hydrazinoalkenes by Et2Zn. Electrophilic capture of the chelated organozinc intermediates drives the subsequent cascade.

  3. Graphical Abstract

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. Graphical Abstract: Angew. Chem. Int. Ed. 52/2014 (pages 14279–14295)

      Article first published online: 17 DEC 2014 | DOI: 10.1002/anie.201490050

  4. Corrigendum

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. You have free access to this content
      Corrigendum: A Concise and Versatile Synthesis of Alkaloids from Kopsia tenuis: Total Synthesis of (±)-Lundurine A and B (page 14295)

      Prof. Shigeru Arai, Masaya Nakajima and Prof. Atsushi Nishida

      Article first published online: 17 DEC 2014 | DOI: 10.1002/anie.201410554

      This article corrects:

      A Concise and Versatile Synthesis of Alkaloids from Kopsia tenuis: Total Synthesis of (±)-Lundurine A and B1

      Vol. 53, Issue 22, 5569–5572, Article first published online: 25 MAY 2014

  5. News

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
  6. Author Profile

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. Jagadese J. Vittal (page 14302)

      Article first published online: 4 SEP 2014 | DOI: 10.1002/anie.201407114

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      “My favorite saying is ‘it is never too late to follow your dreams’. If I were not a scientist, I would be a sketch artist …” This and more about Jagadese J. Vittal can be found on page 14302.

  7. News

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
  8. Book Review

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. Lithium Compounds in Organic Synthesis. From Fundamentals to Applications. Edited by Renzo Luisi and Vito Capriati. (page 14304)

      Göran Hilmersson

      Article first published online: 3 DEC 2014 | DOI: 10.1002/anie.201409264

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      Wiley-VCH, Weinheim, 2014. 576 pp., hardcover, € 159.00.—ISBN 978-3527333431

  9. Highlights

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. Click Chemistry

      Enamine/Enolate-Mediated Organocatalytic Azide–Carbonyl [3+2] Cycloaddition Reactions for the Synthesis of Densely Functionalized 1,2,3-Triazoles (pages 14310–14312)

      Prof. Dr. Sripada S. V. Ramasastry

      Article first published online: 17 NOV 2014 | DOI: 10.1002/anie.201409410

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      Organocatalytic click! Recent advances in the metal-free enamine/enolate-mediated azide–carbonyl [3+2] cycloaddition reaction are discussed. These approaches require neither a metal catalyst nor alkyne substrates. Owing to the ready availability of carbonyl compounds, these methods thus offer excellent alternatives for the synthesis of 1,4-/1,5-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles.

    2. Asymmetric Catalysis

      Building Up Quarternary Stereocenters of Chromans by Asymmetric Redox Organocatalysis: A New Entry to Vitamin E (pages 14313–14315)

      Dr. Thomas Netscher

      Article first published online: 13 NOV 2014 | DOI: 10.1002/anie.201409826

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      High-turnover catalysis offers a novel concept for the efficient chemo- and enantioselective preparation of chroman intermediates, which are useful for the synthesis of tocopherols (vitamin E components) and other biologically active compounds. A chiral ammonium iodide catalyst mediates the cycloetherification in combination with a cooxidant and an inorganic base in excellent yield and up to 93 % ee. OTs=para-toluenesulfonyl.

  10. Essay

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. History of Science

      Michael Kasha: From Photochemistry and Flowers to Spectroscopy and Music (pages 14316–14324)

      Prof. Alexander P. Demchenko, Prof. Józef Heldt, Prof. Jacek Waluk, Prof. Pi-Tai Chou, Prof. Pradeep K. Sengupta, Prof. Larissa Brizhik and Prof. Juan Carlos del Valle

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201405222

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      A brilliant scientist and an outstanding personality who was one of the founders of modern photochemistry—Michael Kasha—is the subject of this Essay. Kasha's rule and the Kasha effect both bear his name, and he also discovered the chemical production of singlet molecular oxygen, and was a pioneer of excited-state proton transfer systems. Kasha combined his passion for chemistry and physics with that for music, photography, and botany.

  11. Review

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. Nanomaterials

      Diamond Nanowires: Fabrication, Structure, Properties, and Applications (pages 14326–14351)

      Dr. Yuan Yu, Dr. Liangzhuan Wu and Prof. Dr. Jinfang Zhi

      Article first published online: 5 NOV 2014 | DOI: 10.1002/anie.201310803

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      The other carbon 1D nanomaterials: The reproducible synthesis of crystalline diamond nanowires is possible, but has remained difficult. This Review gives an overview of nanowires as materials with exceptional properties, such as negative electron affinity, chemical inertness, high elastic modulus, hardness, and thermal conductivity at room temperature.

  12. Communications

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. Corrigendum
    6. News
    7. Author Profile
    8. News
    9. Book Review
    10. Highlights
    11. Essay
    12. Review
    13. Communications
    1. Heterocycle Synthesis

      Intramolecular Metalloamination of N,N-Dimethylhydrazinoalkenes: A Versatile Method to Access Functionalized Piperidines and Pyrrolidines (pages 14352–14356)

      Bryce Sunsdahl, Adrian R. Smith and Prof. Dr. Tom Livinghouse

      Article first published online: 10 OCT 2014 | DOI: 10.1002/anie.201407768

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      Zinc helps: An attractive way to nitrogen heterocycles uses organozinc intermediates which undergo facile allylation and acylation in situ (see scheme). In general, the products are obtained in excellent yields and diastereoselectivities. In some cases, reduction of the reaction temperature was necessary to reach diastereoselectivity.

    2. Bioimaging

      A Small-Molecule FRET Reporter for the Real-Time Visualization of Cell-Surface Proteolytic Enzyme Functions (pages 14357–14362)

      Jing Mu, Dr. Fang Liu, Muhammad Shafiq Rajab, Meng Shi, Shuang Li, Chiching Goh, Prof. Lei Lu, Prof. Qing-Hua Xu, Prof. Bin Liu, Dr. Lai Guan Ng and Prof. Bengang Xing

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201407182

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      Cell-membrane imaging: A membrane-anchored small-molecule reporter containing a FRET pair (F–Q; F= fluorescein, Q=quencher) was prepared. This molecule is shown to be specifically cleaved by the membrane-localized proteolytic processing enzyme furin (see picture) and was employed in the real-time visualization of furin-like activity in living cells and tissues using one- and two-photon microscopic techniques.

    3. Systems Chemistry

      Kinetic Control over Pathway Complexity in Supramolecular Polymerization through Modulating the Energy Landscape by Rational Molecular Design (pages 14363–14367)

      Dr. Soichiro Ogi, Tomoya Fukui, Melinda L. Jue, Prof. Dr. Masayuki Takeuchi and Dr. Kazunori Sugiyasu

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201407302

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      Finding the right balance: The energy landscape of a supramolecular polymerization in which the supramolecular assembly transforms from a J-aggregate to an H-aggregate over time has been modulated by a rational molecular design. Based on this, kinetic control over pathway complexity was achieved through adjusting the balance between the coupled equilibria.

    4. Water Clusters

      Hydrogen Bond Cooperativity and the Three-Dimensional Structures of Water Nonamers and Decamers (pages 14368–14372)

      Dr. Cristóbal Pérez, Dr. Daniel P. Zaleski, Nathan A. Seifert, Dr. Berhane Temelso, Prof. George C. Shields, Prof. Zbigniew Kisiel and Prof. Brooks H. Pate

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201407447

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      Broadband rotational spectroscopy enabled the observation of three isomers of the water nonamer and two isomers of the water decamer. The distinctive O[BOND]O distance patterns allow a conclusive identification. The observed cooperativity effects are consistent with a simple model for hydrogen bonding in water that takes the cooperative and anticooperative bonding effects of nearby water molecules into account.

    5. Analysis of Paintings

      Detection of Organic Colorants in Historical Painting Layers Using UV Laser Ablation Surface-Enhanced Raman Microspectroscopy (pages 14373–14377)

      Anna Cesaratto, Dr. Marco Leona, Prof. John R. Lombardi, Dr. Daniela Comelli, Dr. Austin Nevin and Dr. Pablo Londero

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408016

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      UV-LA-SERS of paintings: The UV-laser ablation SERS technique can be used for the study of organic paint layers when the sample is properly pretreated and the ablation parameters are carefully controlled. UV-LA-SERS permitted the sampling of cross-sections from selected thin layers, avoiding contamination from adjacent layers.

    6. Sustainable Chemistry | Hot Paper

      Green-Solvent-Processed Molecular Solar Cells (pages 14378–14381)

      Xiaofen Chen, Dr. Xiaofeng Liu, Mark A. Burgers, Dr. Ye Huang and Prof. Dr. Guillermo C. Bazan

      Article first published online: 11 NOV 2014 | DOI: 10.1002/anie.201409208

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      Molecular solar cells with high efficiencies can be fabricated from the green solvent 2-MeTHF. The light-harvesting semiconducting layer comprises a molecular donor with intermediate dimensions and a soluble fullerene derivative. No specific structural modifications are required on the semiconductors in order to use sustainable resources. PCE=power conversion efficiency.

    7. Olefin Functionalization

      Quinone Diazides for Olefin Functionalization (pages 14382–14386)

      Hai T. Dao and Prof. Dr. Phil S. Baran

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408022

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      Teaching an old dog new tricks: The combination of modern catalysis and free quinone diazides allows classic diazo compounds to be utilized for both inter- and intramolecular olefin cyclopropanation reactions with a variety of different olefin classes (see example). The use of suitably masked quinone diazides also provides a fundamentally new approach to steroid skeletons (MOM=methoxymethyl).

    8. Lipid Membranes

      Simultaneous In Situ Quantification of Two Cellular Lipid Pools Using Orthogonal Fluorescent Sensors (pages 14387–14391)

      Dr. Shu-Lin Liu, Dr. Ren Sheng, Matthew J. O'Connor, Yang Cui, Dr. Youngdae Yoon, Svetlana Kurilova, Dr. Daesung Lee and Dr. Wonhwa Cho

      Article first published online: 24 OCT 2014 | DOI: 10.1002/anie.201408153

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      Same time, same place: The time-resolved quantification of multiple lipids in a lipid membrane provides insight into the complex mechanisms of lipid-mediated cell signaling and regulation. Sensors were prepared by incorporating two environmentally sensitive fluorophores with minimal spectral overlap into engineered lipid-binding proteins.

    9. Rotaxanes

      A Doubly Alkynylpyrene-Threaded [4]Rotaxane That Exhibits Strong Circularly Polarized Luminescence from the Spatially Restricted Excimer (pages 14392–14396)

      Prof. Dr. Masahiko Inouye, Koichiro Hayashi, Yuki Yonenaga, Dr. Tatsuya Itou, Dr. Kazuhisa Fujimoto, Taka-aki Uchida, Dr. Munetaka Iwamura and Prof. Dr. Koichi Nozaki

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201408193

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      Facing facts: A pyrene-based [4]rotaxane has been formed by encapsulating two highly emissive alkynylpyrene molecules in two γ-cyclodextrins, followed by stoppering. The pyrene cores exist near the two wider rims of two γ-CD molecules and face each other, thereby generating a spatially restricted, asymmetrically twisted alkynylpyrene excimer that emits circularly polarized luminescence (CPL) with a large dissymmetry factor (glum) in water.

    10. Drug Delivery

      Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo (pages 14397–14401)

      Dr. Omar F. Khan, Edmond W. Zaia, Dr. Hao Yin, Dr. Roman L. Bogorad, Dr. Jeisa M. Pelet, Dr. Matthew J. Webber, Iris Zhuang, Dr. James E. Dahlman, Prof. Robert Langer and Prof. Daniel G. Anderson

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408221

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      Formulation control: Dendrimer derivatives for in vivo siRNA delivery to liver endothelial cells, hepatocellular carcinoma cells, and/or hepatocytes are prepared from poly(amido amine) and poly(propylenimine) dendrimers substituted with alkyl chains of different lengths. Through formulation changes, these materials have the ability to broaden or narrow their targeted cellular subpopulation within the liver.

    11. Enzyme Catalysis

      Extended Reaction Scope of Thiamine Diphosphate Dependent Cyclohexane-1,2-dione Hydrolase: From C[BOND]C Bond Cleavage to C[BOND]C Bond Ligation (pages 14402–14406)

      Dipl.-Chem. Sabrina Loschonsky, Dipl.-Chem. Tobias Wacker, Simon Waltzer, Dr. Pier Paolo Giovannini, Prof. Dr. Michael J. McLeish, Prof. Dr. Susana L. A. Andrade and Prof. Dr. Michael Müller

      Article first published online: 7 NOV 2014 | DOI: 10.1002/anie.201408287

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      The ThDP-dependent enzyme CDH catalyzes an asymmetric benzoin condensation and the C[BOND]C bond cleavage of cyclohexane-1,2-dione. Mutation experiments resulted in the selective knockdown of one of these reactivities; CDH-H28A/N484A catalyzes the addition of pyruvate to cyclohexane-1,2-dione. This variant is one of the few ThDP-dependent enzymes that uses ketones as substrates in a C[BOND]C bond-forming reaction.

    12. CO2 Activation

      Spectroscopic Identification of a Bidentate Binding Motif in the Anionic Magnesium–CO2 Complex ([ClMgCO2]) (pages 14407–14410)

      Glenn B. S. Miller, Tim K. Esser, Harald Knorke, Sandy Gewinner, Dr. Wieland Schöllkopf, Dr. Nadja Heine, Prof. Dr. Knut R. Asmis and Prof. Dr. Einar Uggerud

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201409444

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      Bidentate coordination of CO2: An anionic complex of MgCl and CO2, [ClMgCO2], is formed upon electrospray ionization followed by collision-induced dissociation. With the help of infrared photodissociation spectroscopy it is shown that the complex exists solely in the double oxygen-bound [ClMg(η2-O2C)] form, a type of CO2 coordination not previously seen in unimetallic complexes.

    13. Transition Metals

      Oxidative Metalation as a Route to Size-Mismatched Macrocyclic Complexes: Osmium Corroles (pages 14411–14414)

      Dr. Abraham B. Alemayehu, Dr. Kevin J. Gagnon, Prof. Dr. James Terner and Prof. Dr. Abhik Ghosh

      Article first published online: 24 OCT 2014 | DOI: 10.1002/anie.201405890

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      Last man standing! After the synthesis of platinum corroles, osmium was the last remaining middle and late 5d metal to be inserted into the contracted porphyrin analogue. Oxidative metalation has now provided a moderately high-yielding route to osmium corroles. DEGME=diethylene glycol monomethyl ether.

    14. Reversible DNA Ligation

      Synthesis, Dynamic Combinatorial Chemistry, and PCR Amplification of 3′–5′ and 3′–6′ Disulfide-linked Oligonucleotides (pages 14415–14418)

      Dennis Jul Hansen, Ilenia Manuguerra, Michael Brøndum Kjelstrup and Prof. Kurt Vesterager Gothelf

      Article first published online: 20 NOV 2014 | DOI: 10.1002/anie.201405761

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      Internucleosidic 3′–5′ and 3′–6′ disulfide linkages allows cleavage and template-directed formation of desired disulfides in the presence of mercaptoethanol. The artificial disulfide backbone is tolerated by polymerases and the sequences can be amplified by polymerase chain reaction.

    15. Core–Shell Nanoparticles

      An Upconversion Nanoparticle with Orthogonal Emissions Using Dual NIR Excitations for Controlled Two-Way Photoswitching (pages 14419–14423)

      Jinping Lai, Yixiao Zhang, Nicholas Pasquale and Ki-Bum Lee

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201408219

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      Spiropyran photoswitching: A single-crystal core–shell-structured upconversion nanoparticle (Tm@Er) is capable of orthogonal UV (365 nm) and visible (545 nm) emissions in response to two distinct NIR excitations at 808 and 980 nm. It was applied in NIR-light-based two-way photoswitching of spiropyran.

    16. DNA Crystallography

      Racemic DNA Crystallography (pages 14424–14427)

      Dr. Pradeep K. Mandal, Dr. Gavin W. Collie, Dr. Brice Kauffmann and Dr. Ivan Huc

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201409014

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      DNA, proteins, and small molecules all alike: When mixed in a racemate, DNA D- and L-enantiomers invariably crystallize as a racemate regardless of the sequence and of the folding motif.

    17. P,N Ligands

      A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins (pages 14428–14432)

      Dr. Bo Qu, Dr. Lalith P. Samankumara, Dr. Shengli Ma, Dr. Keith R. Fandrick, Dr. Jean-Nicolas Desrosiers, Dr. Sonia Rodriguez, Dr. Zhibin Li, Dr. Nizar Haddad, Dr. Zhengxu S. Han, Keith McKellop, Scott Pennino, Dr. Nelu Grinberg, Dr. Nina C. Gonnella, Dr. Jinhua J. Song and Dr. Chris H. Senanayake

      Article first published online: 10 NOV 2014 | DOI: 10.1002/anie.201408929

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      Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-dihydronaphthalenes under one atmosphere pressure of H2, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1-tetralones.

    18. Catalyst Design | Hot Paper

      Molybdenum Phosphosulfide: An Active, Acid-Stable, Earth-Abundant Catalyst for the Hydrogen Evolution Reaction (pages 14433–14437)

      Dr. Jakob Kibsgaard and Prof. Thomas F. Jaramillo

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201408222

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      Introducing sulfur into the surface of molybdenum phosphide produces a molybdenum phosphosulfide catalyst with outstanding activity and stability for the hydrogen evolution reaction (HER) in acidic environments. Synergistic effects between sulfur and phosphorus produce an electrode that is more active than those based on either the pure sulfide or the pure phosphide.

    19. Metal–Organic Frameworks

      Pd Uptake and H2S Sensing by an Amphoteric Metal–Organic Framework with a Soft Core and Rigid Side Arms (pages 14438–14442)

      Jieshun Cui, Yan-Lung Wong, Dr. Matthias Zeller, Dr. Allen D. Hunter and Dr. Zhengtao Xu

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408453

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      Yin and yang: A system incorporating both rigid and flexible components has been prepared in which traditional configuration has been reversed by installing rigid side arms onto a soft core (see picture). After binding to PbII ions, the dynamic hard–soft (carboxy–thioether) metal–organic framework has distinct amphoteric character, with the donor-acceptor properties enabling uptake of PdCl2 and a sensitive colorimetric response to H2S.

    20. Cytoprotection

      Cytoprotective Alginate/Polydopamine Core/Shell Microcapsules in Microbial Encapsulation (pages 14443–14446)

      Beom Jin Kim, Taegyun Park, Hee Chul Moon, So-Young Park, Daewha Hong, Eun Hyea Ko, Ji Yup Kim, Jong Wook Hong, Prof. Sang Woo Han, Prof. Yang-Gyun Kim and Prof. Insung S. Choi

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408454

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      All wrapped up: Alginate/polydopamine core/shell microcapsules that encapsulate yeast Saccharomyces cerevisiae cells prevent gel swelling because of the mechanical durability of the polydopamine shell. Encapsulation enhances cell resistance against external stresses, such as enzymatic attack and UV-C irradiation, and effectively prevents cell growth and leakage.

    21. Biocomputing

      DNA-Programmed Dynamic Assembly of Quantum Dots for Molecular Computation (pages 14447–14450)

      Xuewen He, Zhi Li, Muzi Chen and Prof. Nan Ma

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408479

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      It's only logical: A quantum dot (QD)-based molecular computing system is constructed based on the DNA-programmed dynamic assembly of multi-color QDs. A complete set of seven elementary logic gates and a half-adder is realized for QD biocomputing.

    22. Heterocycles

      Synthesis of Highly Functionalized Polycyclic Quinoxaline Derivatives Using Visible-Light Photoredox Catalysis (pages 14451–14455)

      Dr. Zhi He, Minwoo Bae, Dr. Jie Wu and Prof. Dr. Timothy F. Jamison

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201408522

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      Full of nitrogen: Highly functionalized pyrrolo[1,2-a]quinoxalines and other nitrogen-rich polycyclic quinoxaline analogues have been obtained by a visible-light-induced decarboxylative radical cyclization of arylisocyanides using phenyliodine(III) dicarboxylate reagents under mild reaction conditions. A telescoped preparation of these polycyclic compounds has been established by using a three-step continuous-flow system.

    23. Solvatochromism

      Visualizing the Chain-Flipping Mechanism in Fatty-Acid Biosynthesis (pages 14456–14461)

      Dr. Joris Beld, Dr. Hu Cang and Prof. Dr. Michael D. Burkart

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408576

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      Flipping out in style: Protein–protein interactions with the partner protein ketoacyl synthase II (KASII) cause fatty-acid-intermediate cargo sequestered by the acyl carrier protein (ACP) to flip from the hydrophobic core of the carrier protein into the active site of the partner protein. Solvatochromic pantetheine probes were used to visualize this event (see picture).

    24. Coordination Chemistry

      The Mechanisms of Rectification in Au|Molecule|Au Devices Based on Langmuir–Blodgett Monolayers of Iron(III) and Copper(II) Surfactants (pages 14462–14467)

      Lanka D. Wickramasinghe, Dr. Shivnath Mazumder, Sunalee Gonawala, Meeghage Madusanka Perera, Habib Baydoun, Bishnu Thapa, Li Li, Lingxiao Xie, Prof. Guangzhao Mao, Prof. Zhixian Zhou, Prof.  H. Bernhard Schlegel and Prof. Cláudio N. Verani

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408649

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      Current rectification: Iron(III) and copper(II) metallosurfactants were used to study current rectification in Au|molecule|Au devices. An asymmetric mechanism of rectification seems favorable when the energies of the molecular complex orbitals are comparable with the Fermi levels of the gold electrode (see picture).

    25. Water Oxidation

      Catalytic Water Oxidation by Ruthenium(II) Quaterpyridine (qpy) Complexes: Evidence for Ruthenium(III) qpy-N,N′′′-dioxide as the Real Catalysts (pages 14468–14471)

      Yingying Liu, Dr. Siu-Mui Ng, Dr. Shek-Man Yiu, Dr. William W. Y. Lam, Xi-Guang Wei, Dr. Kai-Chung Lau and Prof. Tai-Chu Lau

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201408795

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      What is the real catalyst? A series of ruthenium(II) complexes [Ru(qpy)(L)2]2+ (qpy=2,2′:6′,2′′:6′′,2′′′-quaterpyridine; L=substituted pyridine) function as precatalysts for water oxidation using (NH4)2Ce(NO3)6 (CAN) as the terminal oxidant. In the presence of CAN, they are readily oxidized to the qpy-N,N′′′-dioxide complexes [Ru(ONNO)(L)2]3+, which are the real catalysts for water oxidation.

    26. Asymmetric Synthesis | Hot Paper

      Copper-Catalyzed Asymmetric Synthesis of Tertiary α-Hydroxy Phosphonic Acid Derivatives with In Situ Generated Nitrosocarbonyl Compounds as the Oxygen Source (pages 14472–14475)

      Dr. Biplab Maji and Prof. Dr. Hisashi Yamamoto

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201408893

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      Go for oxygen: The copper-catalyzed direct α-oxidation of racemic β-ketophosphonates using nitrosocarbonyl compounds as an electrophilic oxygen source is a new method for the asymmetric synthesis of biogenic tertiary α-hydroxy phosphonic acid derivatives. Highly efficient asymmetric hydroxylations could thus be achieved at room temperature under mild conditions.

    27. Nanoparticles | Very Important Paper

      Identification and Accurate Size Characterization of Nanoparticles in Complex Media (pages 14476–14479)

      Lihong Liu, Prof. Bin He, Dr. Qian Liu, Dr. Zhaojun Yun, Xueting Yan, Dr. Yanmin Long and Prof. Guibin Jiang

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201408927

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      (Nano)size matters: Capillary electrokinetic separation and inductively coupled plasma mass spectrometry (ICP-MS) were combined in a method that allows the identification and accurate size determination of nanoparticles in complex media (see picture). This method provides a powerful tool for investigating polydisperse multiple NP systems and rapid screening of NP-containing products.

    28. Water Oxidation

      Photocatalytic Water Oxidation by a Pyrochlore Oxide upon Irradiation with Visible Light: Rhodium Substitution Into Yttrium Titanate (pages 14480–14484)

      Borbala Kiss, Dr. Christophe Didier, Timothy Johnson, Dr. Troy D. Manning, Dr. Matthew S. Dyer, Dr. Alexander J. Cowan, Dr. John B. Claridge, Prof. James R. Darwent and Prof. Matthew J. Rosseinsky

      Article first published online: 2 DEC 2014 | DOI: 10.1002/anie.201407179

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      Splitting water: Visible-light-activated water oxidation was achieved using rhodium-substituted pyrochlore yttrium titanate, Y2Ti2−xRhxO7 (0≤x≤0.2). When x≤0.06, the material absorbs visible light up to λ=700 nm. Materials with composition 0.04≤x≤0.06 showed stable oxygen evolution without the need for a co-catalyst.

    29. Synthetic Methods

      Copper-Catalyzed Aerobic Oxidative Transformation of Ketone-Derived N-Tosyl Hydrazones: An Entry to Alkynes (pages 14485–14489)

      Xianwei Li, Xiaohang Liu, Huoji Chen, Dr. Wanqing Wu, Dr. Chaorong Qi and Prof. Dr. Huanfeng Jiang

      Article first published online: 25 NOV 2014 | DOI: 10.1002/anie.201405058

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      The ynes: The title reaction leads to synthetically valuable internal alkynes and diynes. This method features an inexpensive catalyst, O2 as the oxidant, good functional-group tolerance, high regioselectivity, and readily available starting materials. DABCO=1,4-diazabicyclo[2.2.2]octane, Ts=4-toluenesulfonyl.

    30. Phosphorus Nitrides

      Pentacoordinate Phosphorus in a High-Pressure Polymorph of Phosphorus Nitride Imide P4N6(NH) (pages 14490–14493)

      Dominik Baumann and Prof. Dr. Wolfgang Schnick

      Article first published online: 14 AUG 2014 | DOI: 10.1002/anie.201406086

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      Give me five: Pentacoordinate phosphorus is detected for the first time in a high-pressure polymorph of phosphorus nitride imide P4N6(NH). This phase exhibits a new very dense network structure composed of chains of edge-sharing trigonal PN5 bipyramids (see picture) connected by P2N7 double tetrahedra.

    31. Natural Products Synthesis

      Biomimetic Synthesis: Discovery of Xanthanolide Dimers (pages 14494–14498)

      Dr. Hai Shang, Dr. Junhua Liu, Ruiyang Bao, Dr. Yu Cao, Kun Zhao, Chengqian Xiao, Prof. Dr. Bing Zhou, Prof. Dr. Lihong Hu and Prof. Dr. Yefeng Tang

      Article first published online: 27 NOV 2014 | DOI: 10.1002/anie.201406461

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      It takes two: The first biomimetic synthesis of 4β,5β-epoxyxanthatin-1α,4α-endoperoxide has been achieved. Moreover, four unprecedented xanthanolide dimers were synthesized from xanthatin by three different types of dimerizations. Although these dimers were first identified as artifacts in the lab, two of them, mogolides A and B, proved to be naturally occurring substances.

    32. Water Oxidation

      Water Oxidation Catalyzed by a Dinuclear Cobalt–Polypyridine Complex (pages 14499–14502)

      Dr. Hong-Yan Wang, Dr. Edgar Mijangos, Dr. Sascha Ott and Dr. Anders Thapper

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201406540

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      Light-driven oxygen evolution: A dinuclear cobalt complex has been synthesized as a molecular and homogeneous catalyst for light-driven and electrochemical water oxidation. The catalyst can efficiently promote oxygen evolution under visible-light irradiation at near neutral pH in the presence of a ruthenium-based photosensitizer and an electron acceptor.

    33. Mass Spectrometry

      Development of Coated Blade Spray Ionization Mass Spectrometry for the Quantitation of Target Analytes Present in Complex Matrices (pages 14503–14507)

      M. Sc. German Augusto Gómez-Ríos and Prof. Janusz Pawliszyn

      Article first published online: 10 NOV 2014 | DOI: 10.1002/anie.201407057

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      There's no hiding now: Coated blade spray is a technique based on solid-phase microextraction that has been designed for the quick extraction/cleanup of analytes from complex matrices and direct desorption/ionization under ambient MS conditions. The entire analytical process can be completed within 3 min (see picture; HV=high voltage, SRM=selected reaction monitoring) with limits of quantitation in the low picogram-per-millimeter region.

    34. Ligand Design

      Photomechanical Actuation of Ligand Geometry in Enantioselective Catalysis (pages 14508–14511)

      Zachary S. Kean, Dr. Sergey Akbulatov, Dr. Yancong Tian, Prof. Ross A. Widenhoefer, Dr. Roman Boulatov and Prof. Stephen L. Craig

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201407494

      Thumbnail image of graphical abstract

      Make the switch: A molecular switch mechanically distorts a chiral ligand, thus generating forces on the order of 100 pN and leading to measureable changes in the enantioselectivities of asymmetric Heck arylations and Trost allylic alkylations.

    35. Gold Complexes

      Enhanced π-Backdonation from Gold(I): Isolation of Original Carbonyl and Carbene Complexes (pages 14512–14516)

      Dr. Maximilian Joost, Dr. Laura Estévez, Sonia Mallet-Ladeira, Dr. Karinne Miqueu, Dr. Abderrahmane Amgoune and Dr. Didier Bourissou

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201407684

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      A gift from gold: Bending was shown to significantly enhance π-backdonation in gold(I) complexes. This strategy gives access to the first classical carbonyl complex of gold and allows the isolation of a diphenyl carbene complex that is stabilized by the gold fragment rather than the carbene substituents. The structures of these new complexes were thoroughly analyzed by spectroscopic, crystallographic, and computational means.

    36. Protein Glycosylation

      Synthesis of and Specific Antibody Generation for Glycopeptides with Arginine N-GlcNAcylation (pages 14517–14521)

      Man Pan, Shan Li, Xiang Li, Prof. Dr. Feng Shao, Prof. Dr. Lei Liu and Prof. Dr. Hong-Gang Hu

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201407824

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      Arginine­ N-GlcNAcylation: Chemical synthesis and specific antibody generation of glycopeptides with N-GlcNAcyl groups was accomplished. This enables the generation of highly reactive and specific antibodies for the enrichment and detection of arginine N-GlcNAcylated glycoproteins.

    37. Total Synthesis

      Total Synthesis of Gracilioether F: Development and Application of Lewis Acid Promoted Ketene–Alkene [2+2] Cycloadditions and Late-Stage C[BOND]H Oxidation (pages 14522–14526)

      Christopher M. Rasik and Prof. M. Kevin Brown

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201408055

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      Controlled oxidation: Gracilioether F can be synthesized from norbornadiene in only eight steps while avoiding the use of protecting groups. Key steps of the synthesis include a Lewis acid promoted [2+2] cycloaddition of a ketene with an olefin and a late-stage carboxylic acid directed C(sp3)[BOND]H oxidation.

    38. Lithiated Nanocrystals

      Colloidal Nanocrystals of Lithiated Group 14 Elements (pages 14527–14532)

      Jacqueline E. Cloud, Dr. Yonglong Wang, Tara S. Yoder, Lauren W. Taylor and Prof. Yongan Yang

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408108

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      Anode materials: An unconventional method has been successfully developed for synthesizing four types of colloidal nanocrystals of lithiated group 14 elements, specifically, Li4.4Si, Li3.75Si, Li4.4Ge, and Li4.4Sn (together denoted as LixZ; see picture). The success was the result of overcoming the challenge of incompatibility of LixZ compounds with all conventional passivating ligands.

    39. Synthetic Methods

      Transfer of Aryl Halide to Alkyl Halide: Reductive Elimination of Alkylhalide from Alkylpalladium Halides Containing syn-β-Hydrogen Atoms (pages 14533–14537)

      Wei Hao, Junnian Wei, Weizhi Geng, Prof. Dr. Wen-Xiong Zhang and Prof. Dr. Zhenfeng Xi

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408341

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      Elimination vs. abstraction: Usually, alkylpalladium halides containing syn-β-hydrogen atoms will undergo β-hydride abstraction to afford the Heck-type products. However, this general knowledge is only conditionally correct. Experimental results show that reductive elimination of alkylhalides from alkylpalladium halides containing syn-β-hydrogen atoms may surpass the β-hydride abstraction or even become exclusive in certain cases.

    40. Nitrimines as Reagents for Metal-Free Formal C(sp2)–C(sp2) Cross-Coupling Reactions (pages 14538–14541)

      Veronica V. Angeles-Dunham, Dr. David M. Nickerson, Devin M. Ray and Prof. Dr. Anita E. Mattson

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408613

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      No metal needed: Nitrimines are employed as powerful reagents for metal-free formal C(sp2)–C(sp2) cross-coupling reactions. This process is tolerant of a wide array of nitrimine and heterocyclic coupling partners giving rise to the corresponding di- or trisubstituted alkenes, typically in high yield and with high stereoselectivity. This method is ideal for the metal-free construction of heterocycle-containing drug targets, such as phenprocoumon.

    41. Heterocycles

      Copper(I)-Catalyzed Three-Component Reaction of Terminal Propargyl Alcohols, Aldehydes, and Amines: Synthesis of 3-Amino-2-pyrones and 2,5-Dihydrofurans (pages 14542–14545)

      Wu Fan and Prof. Dr. Shengming Ma

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408826

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      Magic trio: The title reaction proceeds under mild reaction conditions. The reaction involves a sequential A3-coupling, alkyne–allene isomerization, and cycloisomerization to generate α-amino 2,5-dihydrofurans (see scheme; EWG=electron-withdrawing group). In case of using ethyl glyoxalate as the aldehyde, a ring-opening, lactonization, and isomerization process affords the 3-amino-2-pyrones.

    42. Biosynthesis

      C5–C10 Directly Bonded Tetrodotoxin Analogues: Possible Biosynthetic Precursors of Tetrodotoxin From Newts (pages 14546–14549)

      Yuta Kudo, Yoko Yamashita, Prof. Dr. Dietrich Mebs, Dr. Yuko Cho, Prof. Dr. Keiichi Konoki, Prof. Dr. Takeshi Yasumoto and Prof. Dr. Mari Yotsu-Yamashita

      Article first published online: 7 NOV 2014 | DOI: 10.1002/anie.201408913

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      Breaking newt ground: Two tetrodotoxin analogues (2 and 3) were discovered in toxic newts. Their bicyclic carbon skeletons consist of ten carbons, thus suggesting a possible monoterpene origin for tetrodotoxin (TTX, 1). Based on their structural features, Baeyer–Villiger-like oxidation or cleavage of the C5–C10 bond was proposed for the final stage of the biosynthesis of tetrodotoxin.

    43. Organocatalysis

      One-Pot Synthesis of Tri- and Tetrasubstituted Pyridines by Sequential Ring-Opening/Cyclization/Oxidation of N-Arylmethyl 3-Aziridinylpropiolate Esters (pages 14550–14554)

      Prof. Dr. Masahiro Yoshida, Tomotaka Mizuguchi and Prof. Dr. Kosuke Namba

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201409015

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      Small ring, big ring: A novel strategy for the one-pot synthesis of substituted pyridines from N-arylmethyl 3-aziridinylpropiolate esters is described. The method employs a three-step procedure including the formation of allenyl imines, phosphine-catalyzed cyclization, and subsequent oxidation of the dihydropyridines. Depending on the reaction conditions of the final oxidation step, tri- and tetrasubstituted pyridines can be selectively produced.

    44. Natural Product Synthesis

      You have full text access to this OnlineOpen article
      Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation (pages 14555–14558)

      Alice E. Gatland, Dr. Ben S. Pilgrim, Dr. Panayiotis A. Procopiou and Prof. Timothy J. Donohoe

      Article first published online: 27 OCT 2014 | DOI: 10.1002/anie.201409164

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      All in the family: A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium-catalyzed enolate arylation is used to form the isoquinoline core. This modular route allows the rapid synthesis of other members of the protoberberine family (pseudocoptisine and palmatine) by using different coupling partners. Moreover, substituents can be rapidly and regioselectively introduced at the C13 position (dehydrocorydaline). Piv=pivaloyl.

    45. Synthetic Methods

      Trifluoromethoxylation of Arenes: Synthesis of ortho-Trifluoromethoxylated Aniline Derivatives by OCF3 Migration (pages 14559–14563)

      Katarzyna N. Hojczyk, Dr. Pengju Feng, Chengbo Zhan and Prof. Ming-Yu Ngai

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201409375

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      What a move: Trifluoromethoxylation of arenes has been achieved through a thermally induced intramolecular OCF3 migration. This operationally simple protocol, which is amenable to gram-scale synthesis, affords various synthetically useful trifluoromethoxylated aniline derivatives in good yields and with high levels of ortho selectivity.

    46. Energy Storage Devices | Hot Paper

      Flexible and Stretchable Lithium-Ion Batteries and Supercapacitors Based on Electrically Conducting Carbon Nanotube Fiber Springs (pages 14564–14568)

      Ye Zhang, Wenyu Bai, Dr. Xunliang Cheng, Jing Ren, Dr. Wei Weng, Peining Chen, Xin Fang, Zhitao Zhang and Prof. Huisheng Peng

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201409366

      Thumbnail image of graphical abstract

      My flexible friend: Springlike electrodes with remarkable electrochemical properties have been used to create flexible and stretchable fiber-shaped supercapacitors and lithium-ion batteries. The electrodes, which are made from twisted aligned multiwalled carbon nanotubes (see picture), can be stretched by over 300 %, and the devices show stable performance under bending and stretching deformations.

    47. Energy Conversion | Very Important Paper

      Transparent Metal Selenide Alloy Counter Electrodes for High-Efficiency Bifacial Dye-Sensitized Solar Cells (pages 14569–14574)

      Yanyan Duan, Prof. Qunwei Tang, Juan Liu, Dr. Benlin He and Prof. Liangmin Yu

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201409422

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      Transparent counter electrodes consisting of metal selenide binary alloys (Co, Ni, Cu, Fe, Ru) were synthesized and applied in bifacial dye-sensitized solar cells (DSSCs). These solar cells exhibit good energy conversion efficiencies regardless of whether the solar cell is irradiated from the front or from the rear.

    48. C[BOND]H Activation

      Rhodium(III)/Copper(II)-Promoted trans-Selective Heteroaryl Acyloxylation of Alkynes: Stereodefined Access to trans-Enol Esters (pages 14575–14579)

      Manh V. Pham and Prof. Dr. Nicolai Cramer

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201409450

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      What a pair: A RhIII/CuII-promoted process is reported to provide tetrasubstituted enol esters in a trans-selective fashion. This three-component reaction uses a rhodium(III) catalyst for the C2-selective activation of electron-rich heteroarenes and the addition across the alkyne. Copper(II) then takes over to forge the vinyl ester bond. The method was also used for the functionalization of bioactive furocoumarin natural products.

    49. Click Chemistry | Hot Paper

      “Photoclick” Postsynthetic Modification of DNA (pages 14580–14582)

      Dipl.-Chem. Stefanie Arndt and Prof. Dr. Hans-Achim Wagenknecht

      Article first published online: 30 OCT 2014 | DOI: 10.1002/anie.201407874

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      A light click away: The diaryltetrazole group at the 5-position of 2′-deoxyuridine allows the photoinduced postsynthetic modification with maleimide-functionalized sulfo-Cy3 dye.

    50. Bacterial Adhesion

      Switching of Bacterial Adhesion to a Glycosylated Surface by Reversible Reorientation of the Carbohydrate Ligand (pages 14583–14586)

      Theresa Weber, Dr. Vijayanand Chandrasekaran, Insa Stamer, Prof. Dr. Mikkel B. Thygesen, Prof. Dr. Andreas Terfort and Prof. Dr. Thisbe K. Lindhorst

      Article first published online: 27 NOV 2014 | DOI: 10.1002/anie.201409808

      Thumbnail image of graphical abstract

      To bind or not to bind: Although azobenzene α-mannosides are good ligands for the bacterial adhesins in both isomeric forms (E and Z), photochemical reorientation of the α-mannosyl moieties within a biorepulsive monolayer (as a glycocalyx model) can reversibly alter the adhesion of bacterial cells to the surface.

    51. Helical Structures | Very Important Paper

      Inducing Axial Chirality in a “Geländer” Oligomer by Length Mismatch of the Oligomer Strands (pages 14587–14591)

      Michel Rickhaus, Linda Maria Bannwart, Dr. Markus Neuburger, Heiko Gsellinger, Kaspar Zimmermann, Dr. Daniel Häussinger and Prof. Dr. Marcel Mayor

      Article first published online: 3 NOV 2014 | DOI: 10.1002/anie.201408424

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      A molecular dance ribbon: Similar to a dance ribbon pirouetting around its handling stick, an elongated second oligomer wraps itself around the oligophenyl backbone, thereby inducing chirality, in a new type of “Geländer” structure. The new helical molecule was fully characterized and the racemization behavior elucidated.

    52. Configuration Determination

      Axially Chiral BODIPY DYEmers: An Apparent Exception to the Exciton Chirality Rule (pages 14592–14595)

      Dr. Torsten Bruhn, Dr. Gennaro Pescitelli, Sandro Jurinovich, Anu Schaumlöffel, Franziska Witterauf, Dr. Johannes Ahrens, Prof. Dr. Martin Bröring and Prof. Dr. Gerhard Bringmann

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408398

      Thumbnail image of graphical abstract

      The strong magnetic transition dipole moment of the first π–π* transition of the BODIPY chromophore has a high impact on the chiroptical properties of BODIPY dimers. The μm coupling overcomes the μμ coupling and thus the exciton chirality method is no longer applicable for this biaryl system.

    53. Atmospheric Chemistry

      Rapid Autoxidation Forms Highly Oxidized RO2 Radicals in the Atmosphere (pages 14596–14600)

      Tuija Jokinen, Dr. Mikko Sipilä, Stefanie Richters, Prof. Veli-Matti Kerminen, Dr. Pauli Paasonen, Dr. Frank Stratmann, Dr. Douglas Worsnop, Prof. Markku Kulmala, Dr. Mikael Ehn, Prof. Hartmut Herrmann and Dr. Torsten Berndt

      Article first published online: 29 OCT 2014 | DOI: 10.1002/anie.201408566

      Thumbnail image of graphical abstract

      Not only in the solution phase: Highly oxidized RO2 radicals in the atmosphere are rapidly formed by autoxidation initiated by the reaction of O3 and OH radicals with biogenic emissions such as limonene and α-pinene. Field measurements (see picture) confirm experimental findings from a flow-tube study. The closed-shell products from this process represent important aerosol constituents influencing aerosol–cloud–climate interactions.

    54. Solvation Dynamics

      Solvation Dynamics of a Single Water Molecule Probed by Infrared Spectra—Theory Meets Experiment (pages 14601–14604)

      Matthias Wohlgemuth, Dr. Mitsuhiko Miyazaki, Dr. Martin Weiler, Prof. Makoto Sakai, Prof. Otto Dopfer, Prof. Masaaki Fujii and Prof. Roland Mitrić

      Article first published online: 27 NOV 2014 | DOI: 10.1002/anie.201409047

      Thumbnail image of graphical abstract

      Migration routes: Following a new, generally applicable strategy, simulations of water solvation dynamics around biomolecular structures can be verified reliably by experimental time-resolved infrared spectroscopy. Quantitative details of solvent motion (timescale and reaction path) can thus be obtained at the molecular level.

    55. Antibiotics | Very Important Paper

      Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity (pages 14605–14609)

      Dr. Sascha Baumann, Dr. Jennifer Herrmann, Dr. Ritesh Raju, Dipl.-Ing. Heinrich Steinmetz, Dr. Kathrin I. Mohr, Dr. Stephan Hüttel, Dr. Kirsten Harmrolfs, Prof. Dr. Marc Stadler and Prof. Dr. Rolf Müller

      Article first published online: 15 DEC 2014 | DOI: 10.1002/anie.201409964

      Thumbnail image of graphical abstract

      Against multidrug resistance: A novel chemical scaffold with very pronounced activity against bacterial topoisomerases has been isolated from myxobacteria. Cystobactamid 919-2, as the most active derivative, is a potent antibacterial agent against numerous pathogens, including some Gram-negative species, such as E. coli and A. baumannii (see Scheme; rel and SC denote relaxed and supercoiled E. coli DNA, respectively).

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