A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins (pages 14428–14432)
Dr. Bo Qu, Dr. Lalith P. Samankumara, Dr. Shengli Ma, Dr. Keith R. Fandrick, Dr. Jean-Nicolas Desrosiers, Dr. Sonia Rodriguez, Dr. Zhibin Li, Dr. Nizar Haddad, Dr. Zhengxu S. Han, Keith McKellop, Scott Pennino, Dr. Nelu Grinberg, Dr. Nina C. Gonnella, Dr. Jinhua J. Song and Dr. Chris H. Senanayake
Article first published online: 10 NOV 2014 | DOI: 10.1002/anie.201408929
Air-stable P-chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-dihydronaphthalenes under one atmosphere pressure of H2, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1-tetralones.