Efficient Asymmetric Synthesis of Structurally Diverse P-Stereogenic Phosphinamides for Catalyst Design (pages 5474–5477)
Dr. Zhengxu S. Han, Li Zhang, Yibo Xu, Dr. Joshua D. Sieber, Dr. Maurice A. Marsini, Dr. Zhibin Li, Dr. Jonathan T. Reeves, Dr. Keith R. Fandrick, Nitinchandra D. Patel, Dr. Jean-Nicolas Desrosiers, Dr. Bo Qu, Anji Chen, DiAndra M. Rudzinski, Dr. Lalith P. Samankumara, Dr. Shengli Ma, Dr. Nelu Grinberg, Dr. Frank Roschangar, Dr. Nathan K. Yee, Dr. Guijun Wang, Dr. Jinhua J. Song and Dr. Chris H. Senanayake
Article first published online: 10 MAR 2015 | DOI: 10.1002/anie.201500350
Making a ‘Phos’: A general, efficient, and highly enantioselective method for the synthesis of the title compounds relies on nucleophilic substitution of a chiral phosphinate. These chiral phosphinamides were utilized for the synthesis of readily tunable P-stereogenic Lewis base organocatalysts.