The Chemical Basis of Fungal Bioluminescence (pages 8124–8128)
Dr. Konstantin V. Purtov, Dr. Valentin N. Petushkov, Dr. Mikhail S. Baranov, Dr. Konstantin S. Mineev, Dr. Natalja S. Rodionova, Zinaida M. Kaskova, Aleksandra S. Tsarkova, Dr. Alexei I. Petunin, Dr. Vladimir S. Bondar, Dr. Emma K. Rodicheva, Dr. Svetlana E. Medvedeva, Prof. Yuichi Oba, Yumiko Oba, Prof. Alexander S. Arseniev, Prof. Sergey Lukyanov, Prof. Josef I. Gitelson and Dr. Ilia V. Yampolsky
Article first published online: 11 JUN 2015 | DOI: 10.1002/anie.201501779
Getting the green light: Hispidin is shown to be a luciferin precursor in at least four evolutionary distant genera of luminous fungi. However, its biosynthesis alone does not result in fungal bioluminescence. Two enzymes are required: first a hydroxylase converts the hispidin into 3-hydroxyhispidin, which acts as the luciferin, which undergoes a subsequent oxidation in the presence of a luciferase.