Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy (pages 9162–9185)
Prof. Dr. Jan-Henrik Ardenkjaer-Larsen, Prof. Dr. Gregory S. Boebinger, Prof. Dr. Arnaud Comment, Prof. Dr. Simon Duckett, Prof. Dr. Arthur S. Edison, Dr. Frank Engelke, Prof. Dr. Christian Griesinger, Prof. Dr. Robert G. Griffin, Prof. Dr. Christian Hilty, Prof. Dr. Hidaeki Maeda, Prof. Dr. Giacomo Parigi, Prof. Dr. Thomas Prisner, Dr. Enrico Ravera, Prof. Dr. Jan van Bentum, Prof. Dr. Shimon Vega, Prof. Dr. Andrew Webb, Prof. Dr. Claudio Luchinat, Prof. Dr. Harald Schwalbe and Prof. Dr. Lucio Frydman
Article first published online: 1 JUL 2015 | DOI: 10.1002/anie.201410653
A new spin on bio-NMR: This Review presents a state-of-the-art description of the leading approaches being considered today to improve the sensitivity of NMR spectroscopy, particularly as applied in biomolecular settings. The focus is on the future of ultrahigh-field NMR systems, emerging NMR detection technologies, new approaches to nuclear hyperpolarization, and progress in sample preparation.