Angewandte Chemie International Edition

Cover image for Vol. 55 Issue 31

July 25, 2016

Volume 55, Issue 31

Pages 8769–9096

  1. Cover Pictures

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. You have free access to this content
      Cover Picture: Iridium-Catalyzed Enantioselective Hydroalkynylation of Enamides for the Synthesis of Homopropargyl Amides (Angew. Chem. Int. Ed. 31/2016) (page 8769)

      Xiao-Yan Bai, Zi-Xuan Wang and Prof. Dr. Bi-Jie Li

      Version of Record online: 20 MAY 2016 | DOI: 10.1002/anie.201604414

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      An Iridium-Catalyzed asymmetric hydroalkynylation of enamides occur regioselectively at the β position of an enamide. In their Communication on page 9007 ff., B.-J. Li and co-workers report a method for the straightforward synthesis of chiral homopropargyl amides with a stereocenter β to the amide. As illustrated in the cover image, enamide and alkyne undergo rapid union to form a chiral product.

    2. You have free access to this content
      Inside Cover: Atomic-Scale Determination of Active Facets on the MoVTeNb Oxide M1 Phase and Their Intrinsic Catalytic Activity for Ethane Oxidative Dehydrogenation (Angew. Chem. Int. Ed. 31/2016) (page 8770)

      Daniel Melzer, Pinghong Xu, Daniela Hartmann, Dr. Yuanyuan Zhu, Prof. Dr. Nigel D. Browning, Dr. Maricruz Sanchez-Sanchez and Prof. Dr. Johannes A. Lercher

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201605085

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      Catalysis on the edge of complex mixed oxides. In their Communication on page 8873 ff. N. D. Browning, M. Sanchez-Sanchez, J. A. Lercher et al. describe the crystal surface of Mo-V-Te-Nb oxide catalysts by using high-angle annular dark-field scanning transmission electron microscopy, linking the outstanding activity in ethane oxidative dehydrogenation of these materials to the atomic arrangement of particular crystalline facets.

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      Inside Back Cover: Os2–Os4 Switch Controls DNA Knotting and Anticancer Activity (Angew. Chem. Int. Ed. 31/2016) (page 9097)

      Dr. Ying Fu, Dr. María J. Romero, Dr. Luca Salassa, Dr. Xi Cheng, Dr. Abraha Habtemariam, Dr. Guy J. Clarkson, Dr. Ivan Prokes, Prof. Alison Rodger, Prof. Giovanni Costantini and Prof. Peter J. Sadler

      Version of Record online: 6 JUN 2016 | DOI: 10.1002/anie.201605030

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      Marked differences in the interactions of OsII arene metallacycles with DNA might contribute to their antiproliferative activity. In their Communication on page 8909 ff., P. J. Sadler and co-workers describe two tetranuclear organometallic OsII complexes that show significant differences in cytotoxicity against cancer cells and behavior towards DNA condensation. They show a correlation between the organo–osmium metallacycle spacer length, stability in solution, and biological activity.

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      Back Cover: Using Single-Cell Amperometry To Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis (Angew. Chem. Int. Ed. 31/2016) (page 9098)

      Dr. Xianchan Li, Johan Dunevall and Prof. Andrew G. Ewing

      Version of Record online: 31 MAY 2016 | DOI: 10.1002/anie.201605032

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      Chemotherapy with cisplatin induces mild cognitive impairment ("chemo brain"), including memory loss, difficulties with multitasking and focusing, and confusion. In their Communication on page 9041 ff., A. G. Ewing et al. use amperometry and intracellular electrochemical cytometry to show that low concentrations of cisplatin stimulate catecholamine release, whereas high concentrations inhibit this process. Cisplatin appears to regulate release during exocytosis via the fusion pore and not via the vesicle content.

  2. Frontispiece

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. You have free access to this content
      Frontispiece: Stable Aqueous Photoelectrochemical CO2 Reduction by a Cu2O Dark Cathode with Improved Selectivity for Carbonaceous Products

      Xiaoxia Chang, Dr. Tuo Wang, Dr. Peng Zhang, Yijia Wei, Jiubing Zhao and Prof. Dr. Jinlong Gong

      Version of Record online: 20 JUL 2016 | DOI: 10.1002/anie.201683161

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      Photocatalysis. Using Cu2O as a dark cathode, J. Gong and co-workers show in their Communication on page 8840 ff., that it can preferentially reduce CO2 to fuels while suppressing the hydrogen evolution reaction.

  3. Graphical Abstract

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
  4. News

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
  5. Author Profiles

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. Russell Morris (page 8794)

      Version of Record online: 25 FEB 2016 | DOI: 10.1002/anie.201601281

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      “When I was eighteen I wanted to be a professional cricketer. My favorite drink is cup of tea (how very British!) ...” This and more about Russell Morris can be found on page 8794.

  6. Book Reviews

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. Organic Synthesis Using Biocatalysis. Edited by Jon Stewart and Animesh Goswami. (page 8795)

      Nicholas J. Turner

      Version of Record online: 6 JUL 2016 | DOI: 10.1002/anie.201605819

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      Elsevier, Amsterdam 2016. 438 pp., hardcover, € 108.00.—ISBN 978-0124115187

  7. Essays

    1. Top of page
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    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. Alternative Fuels

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      Nitrogen-Based Fuels: A Power-to-Fuel-to-Power Analysis (pages 8798–8805)

      Dr. Alon Grinberg Dana, Oren Elishav, Prof. André Bardow, Dr. Gennady E. Shter and Prof. Gideon S. Grader

      Version of Record online: 10 JUN 2016 | DOI: 10.1002/anie.201510618

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      What are the fuels of the future? Seven representative carbon- and nitrogen-based fuels are evaluated on an energy basis in a power-to-fuel-to-power analysis as possible future chemical hydrogen-storage media. It is intriguing to consider that a nitrogen economy, where hydrogen obtained from water splitting is chemically stored on abundant nitrogen in the form of a nontoxic and safe nitrogen-based alternative fuel, is energetically feasible.

  8. Minireviews

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. Drug Delivery

      Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona (pages 8806–8815)

      Dr. Susanne Schöttler, Prof. Dr. Katharina Landfester and Prof. Dr. Volker Mailänder

      Version of Record online: 15 JUN 2016 | DOI: 10.1002/anie.201602233

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      Stealth shield: The use of nanocarriers in medical applications is complicated by the formation of a protein corona on the nanocarrier surface. This can influence interaction with cell membranes, and makes it difficult to predict cellular interactions, biodistribution, and toxicity. This Minireview provides an overview of what we know about the protein corona of nanocarriers, with a focus on surface functionalization to reduce unspecific uptake—termed the stealth effect.

  9. Reviews

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. 2D Nanomaterials

      Solution-Processed Two-Dimensional MoS2 Nanosheets: Preparation, Hybridization, and Applications (pages 8816–8838)

      Xiao Zhang, Zhuangchai Lai, Chaoliang Tan and Prof. Hua Zhang

      Version of Record online: 22 JUN 2016 | DOI: 10.1002/anie.201509933

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      Sheets ahead: Solution-based methods offer an effective route for the preparation of MoS2 nanosheets. With the an emphasis on applications, the synthetic strategies and methods for functionalization and hybridization are discussed.

  10. Communications

    1. Top of page
    2. Cover Pictures
    3. Frontispiece
    4. Graphical Abstract
    5. News
    6. Author Profiles
    7. Book Reviews
    8. Essays
    9. Minireviews
    10. Reviews
    11. Communications
    1. Photocatalysis | Very Important Paper

      Stable Aqueous Photoelectrochemical CO2 Reduction by a Cu2O Dark Cathode with Improved Selectivity for Carbonaceous Products (pages 8840–8845)

      Xiaoxia Chang, Dr. Tuo Wang, Dr. Peng Zhang, Yijia Wei, Jiubing Zhao and Prof. Dr. Jinlong Gong

      Version of Record online: 20 MAY 2016 | DOI: 10.1002/anie.201602973

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      Copper on the dark side: Cu2O preferentially reduced CO2 to fuels while suppressing hydrogen evolution. It was found that the photogenerated holes primarily account for the instability of Cu2O. The Cu2O was used as a dark cathode to minimize the adverse effects of holes, achieving excellent stability and a selectivity of 92.6 % for carbonaceous products in CO2 photoreduction.

    2. Synthetic Biology

      Engineering a Chemical Switch into the Light-driven Proton Pump Proteorhodopsin by Cysteine Mutagenesis and Thiol Modification (pages 8846–8849)

      Dr. Daniel Harder, Stephan Hirschi, Zöhre Ucurum, Roland Goers, Prof. Dr. Wolfgang Meier, Prof. Dr. Daniel J. Müller and Prof. Dr. Dimitrios Fotiadis

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201601537

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      A chemical switch: Light-driven proton pumps like proteorhodopsin (PR; gray structure with retinal cofactor in magenta) are excellent candidates for efficient energy conversion. The versatility of PR was extended by means of an on/off switch based on reversible chemical modification of a site-specifically introduced cysteine residue. Chemical modification of this residue (green/yellow/red) blocks the channel and abolishes proton pumping under illumination.

    3. Heterogeneous Catalysis | Hot Paper

      Nitrogen-Doped Ordered Mesoporous Carbon Supported Bimetallic PtCo Nanoparticles for Upgrading of Biophenolics (pages 8850–8855)

      Dr. Guang-Hui Wang, Dr. Zhengwen Cao, Dr. Dong Gu, Norbert Pfänder, Ann-Christin Swertz, Bernd Spliethoff, Hans-Josef Bongard, Dr. Claudia Weidenthaler, Dr. Wolfgang Schmidt, Dr. Roberto Rinaldi and Prof. Dr. Ferdi Schüth

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201511558

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      The phenol cut: A novel method allows the synthesis of bimetallic PtCo nanoparticles (ca.1.5 nm) which are highly dispersed in the framework of nitrogen-doped ordered mesoporous carbon (NOMC). The resulting PtCo-NOMC shows high catalytic activity for hydrodeoxygenation of phenolic compounds and “real-world” biomass-derived phenolic streams.

    4. Molecular Magnetism

      You have full text access to this OnlineOpen article
      [CrF(O2CtBu)2]9: Synthesis and Characterization of a Regular Homometallic Ring with an Odd Number of Metal Centers and Electrons (pages 8856–8859)

      Robert J. Woolfson, Dr. Grigore A. Timco, Dr. Alessandro Chiesa, Dr. Inigo J. Vitorica-Yrezabal, Dr. Floriana Tuna, Dr. Tatiana Guidi, Prof. Eva Pavarini, Prof. Paolo Santini, Prof. Stefano Carretta and Prof. Richard E. P. Winpenny

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201601734

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      Spin frustration: The first homometallic wheel compound containing an odd number of metal centers and an odd number of electrons has been synthesized. The extent of spin frustration in the ring has been characterized spectroscopically, showing a near perfect frustrated ground state from a sterically undemanding chemical structure.

    5. DNA Nanotechnology

      Self-Assembly of Complex DNA Tessellations by Using Low-Symmetry Multi-arm DNA Tiles (pages 8860–8863)

      Dr. Fei Zhang, Shuoxing Jiang, Dr. Wei Li, Ashley Hunt, Prof. Yan Liu and Prof. Hao Yan

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201601944

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      Tiny tiling: Two novel Archimedean tiling patterns, (4.8.8) and (3.6.3.6), and one pattern with higher-order structures beyond the complexity observed in Archimedean tiling were achieved through the self-assembly of DNA tiles. Such complicated DNA structures expand the complexity boundaries of DNA tile-based tessellation.

    6. Perovskite Stability

      Organolead Halide Perovskite Nanocrystals: Branched Capping Ligands Control Crystal Size and Stability (pages 8864–8868)

      Binbin Luo, Prof. Ying-Chih Pu, Sarah A. Lindley, Yi Yang, Liqiang Lu, Prof. Yat Li, Prof. Xueming Li and Prof. Jin Z. Zhang

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201602236

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      Perovskite nanocrystals: Variously sized perovskite nanocrystals (PNCs) with high photoluminescence quantum yield and uniformity have been synthesized using branched ligands (APTES). APTES-capped PNCs show high stability in protic solvents because the steric and hydrolysis properties of APTES prevent protic reactions with the core of PNCs.

    7. DNA Nanotechnology

      Computer-Aided Production of Scaffolded DNA Nanostructures from Flat Sheet Meshes (pages 8869–8872)

      Erik Benson, Abdulmelik Mohammed, Dr. Alessandro Bosco, Dr. Ana I. Teixeira, Prof. Pekka Orponen and Dr. Björn Högberg

      Version of Record online: 15 JUN 2016 | DOI: 10.1002/anie.201602446

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      Flat-sheet DNA nanostructures: Using algorithmic tools, DNA nanostructures were designed from 2D meshes with varying internal geometries. Using this method, structures with complex internal and external features were prepared that self-assemble under physiological salt concentrations and have larger surface areas compared to classic DNA origami flat-sheet designs.

    8. Heterogeneous Catalysis

      Atomic-Scale Determination of Active Facets on the MoVTeNb Oxide M1 Phase and Their Intrinsic Catalytic Activity for Ethane Oxidative Dehydrogenation (pages 8873–8877)

      Daniel Melzer, Pinghong Xu, Daniela Hartmann, Dr. Yuanyuan Zhu, Prof. Dr. Nigel D. Browning, Dr. Maricruz Sanchez-Sanchez and Prof. Dr. Johannes A. Lercher

      Version of Record online: 16 MAR 2016 | DOI: 10.1002/anie.201600463

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      Surface structures: High-angle annular dark-field scanning transmission electron microscopy analysis provided an atomic level description of the termination of M1 phase crystals of MoVTeNbOx catalysts. The statistical analysis of electron microscopy images combined with reaction kinetics allowed identification of those crystalline facets active in ethane oxidative dehydrogenation.

    9. Flow Reactions

      You have full text access to this OnlineOpen article
      Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp3)−H Activation (pages 8878–8883)

      Jacek Zakrzewski, Adam P. Smalley, Dr. Mikhail A. Kabeshov, Prof. Matthew J. Gaunt and Prof. Alexei A. Lapkin

      Version of Record online: 15 JUN 2016 | DOI: 10.1002/anie.201602483

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      Keep up with the flow! A predictive mechanistic model was developed and used to design a flow process for C−H activation. The resulting continuous-flow synthesis of aziridines through palladium-catalyzed C(sp3)−H activation was combined with ring opening of the aziridine in flow to give highly functionalized aliphatic amines in a consecutive process involving the capture and release of the aziridine intermediate (see scheme).

    10. Molecular Devices | Hot Paper

      Alcohol-Mediated Resistance-Switching Behavior in Metal–Organic Framework-Based Electronic Devices (pages 8884–8888)

      Dr. Yaqing Liu, Dr. Hong Wang, Dr. Wenxiong Shi, Dr. Weina Zhang, Dr. Jiancan Yu, Bevita K. Chandran, Chenlong Cui, Bowen Zhu, Zhiyuan Liu, Dr. Bin Li, Cai Xu, Zhiling Xu, Prof. Shuzhou Li, Prof. Wei Huang, Prof. Fengwei Huo and Prof. Xiaodong Chen

      Version of Record online: 17 JUN 2016 | DOI: 10.1002/anie.201602499

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      A MOF never forgets: Alcohol-mediated memory devices with reliable resistance-switching properties were realized in metal–organic framework (MOF) films. The memory behavior can be controlled by the intermolecular interactions among the guest molecules adsorbed in MOF crystals to achieve multilevel information storage.

    11. Drug Bioconjugates

      N-Heterocyclic Carbene–Gold(I) Complexes Conjugated to a Leukemia-Specific DNA Aptamer for Targeted Drug Delivery (pages 8889–8893)

      Weijia Niu, Xigao Chen, Weihong Tan and Adam S. Veige

      Version of Record online: 17 JUN 2016 | DOI: 10.1002/anie.201602702

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      Apt to enter cancer cells: N-Heterocyclic carbene (NHC)–gold(I) complexes were conjugated to the CCRF-CEM leukemia-specific aptamer sgc8c as a strategy for the selective targeting of cancer cells. Cell-viability assays in combination with other techniques indicated that the NHC–AuI–aptamer conjugate (see structure) was more cytotoxic than the NHC–gold complex alone and targeted CCRF-CEM leukemia cells selectively.

    12. Nanoparticles

      Luminescent Gold Nanoparticles with Size-Independent Emission (pages 8894–8898)

      Dr. Jinbin Liu, Paul N. Duchesne, Dr. Mengxiao Yu, Xingya Jiang, Xuhui Ning, Rodrigo D. Vinluan III, Prof. Dr. Peng Zhang and Prof. Dr. Jie Zheng

      Version of Record online: 27 JUN 2016 | DOI: 10.1002/anie.201602795

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      Size-independent emission has been widely observed for ultrasmall thiolated gold nanoparticles (AuNPs). Herein, the emission wavelength of thiolated AuNPs is found to depend on the surface coverage and local binding geometry of the thiolate ligands (glutathione) on the AuNP; AuNPs with different surface coverages emit at different wavelengths in spite of their identical size (ca. 2.5 nm).

    13. Supramolecular Chemistry

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      Supramolecular Control over Split-Luciferase Complementation (pages 8899–8903)

      Dr. Ralph P. G. Bosmans, Jeroen M. Briels, Dr. Lech-Gustav Milroy, Dr. Tom F. A. de Greef, Prof. Maarten Merkx and Prof. Luc Brunsveld

      Version of Record online: 29 JUN 2016 | DOI: 10.1002/anie.201602807

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      Cucurbit[8]uril-based supramolecular complementation of split-luciferase allows exact control over the level of enzyme activity with a maximum 20-fold activity enhancement. Competitive small-molecule cucurbit[8]uril binders allow the underlying binding characteristics to be elucidated and a system featuring switchable enzyme activity to be developed.

    14. Solid-State NMR Spectroscopy

      19F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials (pages 8904–8908)

      Karol P. Nartowski, Diksha Malhotra, Dr. Lucy E. Hawarden, Dr. Juraj Sibik, Dr. Dinu Iuga, Dr. J. Axel Zeitler, Dr. László Fábián and Prof. Yaroslav Z. Khimyak

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/anie.201602936

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      Detailed mechanistic insight into the crystallization of flufenamic acid (FFA) in the confined environment of mesoporous silica materials with different pore diameters (3.2–29 nm) was obtained by 19F magic-angle-spinning NMR spectroscopy. This approach provided direct experimental evidence for the formation of a molecular-liquid-like layer besides crystalline confined FFA form I.

    15. Anticancer Complexes

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      Os2–Os4 Switch Controls DNA Knotting and Anticancer Activity (pages 8909–8912)

      Dr. Ying Fu, Dr. María J. Romero, Dr. Luca Salassa, Dr. Xi Cheng, Dr. Abraha Habtemariam, Dr. Guy J. Clarkson, Dr. Ivan Prokes, Prof. Alison Rodger, Prof. Giovanni Costantini and Prof. Peter J. Sadler

      Version of Record online: 30 MAY 2016 | DOI: 10.1002/anie.201602995

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      DNA and osmium tie the knot: Two OsII tetranuclear metallacycle frameworks constructed by linking inactive dihydroxido arene dimers show significant differences in cytotoxicity against cancer cells and behavior toward DNA condensation.

    16. Quorum Sensing

      Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus (pages 8913–8917)

      Prof. Dr. Yftah Tal-Gan, Dr. Monika Ivancic, Dr. Gabriel Cornilescu, Tian Yang and Prof. Dr. Helen E. Blackwell

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201602974

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      Strong words: Lactam analogues of peptidic quorum sensing inhibitors in Staphylococcus aureus have significantly enhanced physical properties, whilst maintaining their strong biological activities. Structural analyses reveal that they adopt conformations similar to their thioester precursors, and corroborate their activities in cell-based assays for AgrC-type receptor modulation.

    17. Protein Modifications

      Synthetic Nucleosomes Reveal that GlcNAcylation Modulates Direct Interaction with the FACT Complex (pages 8918–8922)

      Ritu Raj, Lukas Lercher, Prof. Shabaz Mohammed and Prof. Benjamin G. Davis

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201603106

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      Tag and modify: Precise chemical synthesis of a histone glycoprotein and its use in the construction of an entire synthetic GlcNAcylated nucleosome as a fragment of model chromatin has allowed direct interaction with the central FACT complex to be detected. In the picture, the O-GlcNAc (O-linked β-N-acetylglucosamine) residue is shown as a blue square, and the nucleosome is shown as a red/green/gray unit.

    18. C(sp3)−H Fluorination

      The Uranyl Cation as a Visible-Light Photocatalyst for C(sp3)−H Fluorination (pages 8923–8927)

      Julian G. West, T. Aaron Bedell and Prof. Erik J. Sorensen

      Version of Record online: 20 JUN 2016 | DOI: 10.1002/anie.201603149

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      U can do it: The uranyl cation (UO22+) is able to effect the catalytic fluorination of unactivated C(sp3)−H bonds under visible-light irradiation. Uranyl nitrate is highlighted as a convenient molecular C−H abstraction catalyst, which exhibits selectivity that is distinct from previously reported catalytic systems. NFSI: N-fluorobenzenesulfonimide.

    19. Hypervalent Compounds

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      One-Pot C−H Functionalization of Arenes by Diaryliodonium Salts (pages 8928–8932)

      Marcus Reitti, Dr. Piret Villo and Prof. Berit Olofsson

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201603175

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      Without a trace: Nitroarenes are obtained in a sequential one-pot reaction from arenes via diaryliodonium intermediates. Aryl azides can also be synthesized with this novel approach, where iodine(III) reagents with two carbon ligands are formed in situ from iodine(I), and subsequently reacted with nucleophiles. The presented one-pot method is an important step towards catalytic reactions with these hypervalent iodine reagents. mCPBA=m-chloroperbenzoic acid.

    20. Radical Reactions

      A Supramolecularly Activated Radical Cation for Accelerated Catalytic Oxidation (pages 8933–8937)

      Yang Jiao, Wan-Lu Li, Dr. Jiang-Fei Xu, Dr. Guangtong Wang, Prof. Jun Li, Prof. Zhiqiang Wang and Prof. Xi Zhang

      Version of Record online: 6 JUN 2016 | DOI: 10.1002/anie.201603182

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      Acceleration to dye for: In the Fenton oxidation of a 1,4-diketopyrrolo[3,4-c]pyrrole dye (see scheme), the key electron-deficient radical-cation intermediate was activated by host–guest interactions with electrostatically negative cucurbit[7]uril. A drastic decrease in the apparent activation energy of the transformation, and thus a remarkable improvement in the reaction rate, was observed upon the formation of the supramolecular complex.

    21. Interlocked Molecules

      Formation of Self-Templated 2,6-Bis(1,2,3-triazol-4-yl)pyridine [2]Catenanes by Triazolyl Hydrogen Bonding: Selective Anion Hosts for Phosphate (pages 8938–8943)

      Dr. Joseph P. Byrne, Dr. Salvador Blasco, Anna B. Aletti, Dr. Gary Hessman and Prof. Thorfinnur Gunnlaugsson

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201603213

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      Captured and put in chains: Olefin-appended 2,6-bis(1,2,3-triazol-4-yl)pyridine compounds were able to self-template [2]catenane formation by ring-closing metathesis in up to 50 % yield (see scheme). When screened against a range of ions, the [2]catenanes acted as selective hosts for the tetrahedral phosphate anion, which was bound through triazolyl hydrogen-bonding interactions.

    22. Natural Products

      Bacterial Alkaloids Prevent Amoebal Predation (pages 8944–8947)

      Martin Klapper, Dr. Sebastian Götze, Robert Barnett, Karsten Willing and Dr. Pierre Stallforth

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201603312

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      You eat me, I kill you: A set of bacterial pyrrolizidine alkaloids (pyreudiones A–D) were discovered that protect the producer, Pseudomonas fluorescens HKI0770, against amoebal predation. Isolation, structure elucidation, total synthesis, a proposed biosynthetic pathway for these structures, and gene-deletion experiments are presented.

    23. Caged Biomolecules

      Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging (pages 8948–8952)

      Manuela A. H. Fichte, Xenia M. M. Weyel, Dr. Stephan Junek, Dr. Florian Schäfer, Dr. Cyril Herbivo, Prof. Dr. Maurice Goeldner, Dr. Alexandre Specht, Prof. Dr. Josef Wachtveitl and Prof. Dr. Alexander Heckel

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201603281

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      Now also in 3D! Oligonucleotides with different sequences could be photoactivated with exact three-dimensional control when different two-photon-sensitive photolabile groups were introduced into the strands. Uncaging was visualized by fluorescence as a result of double-strand displacement. By using distinct irradiation conditions, either one of two sequences could be addressed selectively (see left-hand images, which are overlayed on the right).

    24. Hydrogenation Catalysis

      Controlling Ethylene Hydrogenation Reactivity on Pt13 Clusters by Varying the Stoichiometry of the Amorphous Silica Support (pages 8953–8957)

      Dr. Andrew S. Crampton, Marian D. Rötzer, Dr. Florian F. Schweinberger, Dr. Bokwon Yoon, Prof. Dr. Uzi Landman and Prof. Dr. Ueli Heiz

      Version of Record online: 29 JUN 2016 | DOI: 10.1002/anie.201603332

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      Precise control of thin-film stoichiometry, and application of such films as heterogeneous catalyst supports, enables the investigation of their effect on catalytic reactivity. With the application of a single cluster size as catalyst (Pt13), the deconvolution of individual characteristics imparted by each stoichiometrically unique film is attainable through calculations, and the subsequent influence on a model hydrocarbon reaction is elucidated.

    25. G-Quadruplexes

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      Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA (pages 8958–8961)

      Dr. Chun Kit Kwok, Dr. Aleksandr B. Sahakyan and Prof. Shankar Balasubramanian

      Version of Record online: 29 JUN 2016 | DOI: 10.1002/anie.201603562

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      Chemical probing of RNA G-quadruplexes: A novel strategy, SHALiPE, is used to structurally probe and characterize RNA G-quadruplexes (rG4s) at single-nucleotide resolution. Application of this new method on the human precursor microRNA (pre-miRNA) 149 under Li+, K+, and K+ + pyridostatin (PDS) conditions reveals rG4 structure formation, which inhibits in vitro Dicer processing.

    26. Organocatalysis

      Chiral Allenes via Alkynylogous Mukaiyama Aldol Reaction (pages 8962–8965)

      Dr. Aurélien Tap, Dr. Aurélie Blond, Dr. Vijay N. Wakchaure and Prof. Dr. Benjamin List

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201603649

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      A lean machine: A chiral disulfonimide was designed as a catalyst for an alkynylogous Mukaiyama aldol reaction (see scheme). A broad range of aldehydes and diverse alkynyl-substituted ketene acetals underwent the transformation to deliver chiral allenoates in high yield with excellent regio-, diastereo-, and enantioselectivity. The products can be readily derivatized to furnish highly substituted enantiomerically enriched building blocks.

    27. Reduction | Hot Paper

      Hydrogenation of CO2 to Formic Acid with a Highly Active Ruthenium Acriphos Complex in DMSO and DMSO/Water (pages 8966–8969)

      M. Sc. Kai Rohmann, M. Sc. Jens Kothe, Prof. Dr. Matthias W. Haenel, Prof. Dr. Ulli Englert, Dr. Markus Hölscher and Prof. Dr. Walter Leitner

      Version of Record online: 30 JUN 2016 | DOI: 10.1002/anie.201603878

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      Stable environment: The direct hydrogenation of CO2 into formic acid without the need for amine bases as a product stabilizer is described. Complex 1 shows high catalytic productivity and activity. The dimethylsulfoxide (DMSO)/H2O medium is capable of stabilizing the reaction product thermodynamically, which was rationalized by DFT calculations.

    28. Asymmetric Catalysis

      A Powerful Chiral Phosphoric Acid Catalyst for Enantioselective Mukaiyama–Mannich Reactions (pages 8970–8974)

      Dr. Fengtao Zhou and Prof. Dr. Hisashi Yamamoto

      Version of Record online: 6 JUN 2016 | DOI: 10.1002/anie.201603929

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      A selection of M&M's: 2,4,6-trimethyl-3,5-dinitrophenyl substituents were introduced into the 3,3′-positions of BINOL-derived chiral phosphoric acids. The resulting catalysts exhibit excellent enantioselectivity and good diastereoselectivity in asymmetric Mukaiyama–Mannich reactions of imines with a wide range of ketene silyl acetals.

    29. Imaging | Hot Paper

      Cross-Platform DNA Encoding for Single-Cell Imaging of Gene Expression (pages 8975–8978)

      Dr. Pavel Zrazhevskiy, Dr. Shreeram Akilesh, Dr. Wanyi Tai, Konstantin Queitsch, Prof. Lawrence D. True, Prof. Jonathan Fromm, Prof. David Wu, Prof. Peter Nelson, Prof. John A. Stamatoyannopoulos and Prof. Xiaohu Gao

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/anie.201603945

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      Now you see it: DNA encoding chemistry combined with multiplexed imaging enables simultaneous in situ interrogation of a panel of selected DNA, RNA, and/or protein markers (red, blue, and green probes, respectively) in single cells by bringing different target types onto the same detection platform. In a proof-of-concept study with multicolor quantum dot probes, DNA encoding was used to explore the spatial and temporal aspects of cell transfection and RNAi.

    30. Green Chemistry

      Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature (pages 8979–8983)

      Jie Feng, Dr. Sachin Handa, Dr. Fabrice Gallou and Prof. Dr. Bruce H. Lipshutz

      Version of Record online: 15 JUN 2016 | DOI: 10.1002/anie.201604026

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      By design: As a result of a unique synergy between ligand-free Fe/ppm Pd nanoparticles and PEG-containing designer surfactants, a facile and selective reduction of nitro-containing (hetero)aromatics by NaBH4 can be effected in water at room temperature. The process offers a general, environmentally responsible, and notably safe approach to highly valued reductions of nitro-containing compounds.

    31. Molecular Imaging

      A Genetically Encoded β-Lactamase Reporter for Ultrasensitive 129Xe NMR in Mammalian Cells (pages 8984–8987)

      Yanfei Wang, Benjamin W. Roose, Eugene J. Palovcak, Dr. Vincenzo Carnevale and Prof. Ivan J. Dmochowski

      Version of Record online: 15 JUN 2016 | DOI: 10.1002/anie.201604055

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      Xenon-assisted MRI: TEM-1 β-lactamase (bla) is a single-protein reporter for hyperpolarized 129Xe NMR, with significant saturation contrast. Xenon chemical exchange saturation transfer interactions with an allosteric site in bla give rise to a unique saturation peak at 255 ppm, well removed from the 129Xe-H2O peak, and allowed bla to be detected in bacterial and mammalian cells.

    32. Electrochemistry

      An Aurivillius Oxide Based Cathode with Excellent CO2 Tolerance for Intermediate-Temperature Solid Oxide Fuel Cells (pages 8988–8993)

      Yinlong Zhu, Prof. Wei Zhou, Dr. Yubo Chen and Prof. Zongping Shao

      Version of Record online: 13 JUN 2016 | DOI: 10.1002/anie.201604160

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      The Aurivillius oxide Bi2Sr2Nb2MnO12−δ is a highly promising cathode material with excellent CO2 tolerance for intermediate-temperature solid oxide fuel cells. This cathode not only shows high activity in the oxygen reduction reaction, but also exhibits a very low thermal expansion coefficient, excellent structural stability, and good chemical compatibility with the electrolyte.

    33. Multicomponent Reactions | Hot Paper

      Insertion of Isocyanides into N−Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds (pages 8994–8998)

      Kranti G. Kishore, Ouldouz Ghashghaei, Dr. Carolina Estarellas, M. Mar Mestre, Cristina Monturiol, Dr. Nicola Kielland, Prof. John M. Kelly, Dr. Amanda Fortes Francisco, Shiromani Jayawardhana, Prof. Diego Muñoz-Torrero, Prof. Belén Pérez, Prof. F. Javier Luque, Prof. Rocío Gámez-Montaño and Prof. Rodolfo Lavilla

      Version of Record online: 17 JUN 2016 | DOI: 10.1002/anie.201604109

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      Insert here! Multicomponent reactions (MCRs) with isoquinolines and other azines that proceed through the insertion of an isocyanide into a N−Si bond are described. This novel activation mode enables a variety of transformations to take place with high selectivity under mild reaction conditions. Some of the products showed in vitro activity against the causative agents of trypanosomiasis. TMS=trimethylsilyl.

    34. Perovskite Solar Cells | Hot Paper

      Hexaazatrinaphthylene Derivatives: Efficient Electron-Transporting Materials with Tunable Energy Levels for Inverted Perovskite Solar Cells (pages 8999–9003)

      Dr. Dongbing Zhao, Dr. Zonglong Zhu, Prof. Dr. Ming-Yu Kuo, Dr. Chu-Chen Chueh and Prof. Dr. Alex K.-Y. Jen

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201604399

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      Only sulfur has the answer: Fine tuning of the energy levels and solution processability of hexaazatrinaphthylene (HATNA) derivatives is achieved by introducing alkylsulfanyl chains of various chain lengths and with different sulfur oxidation states. Perovskite solar cells employing these HATNA derivatives as electron-transporting materials exhibited excellent performances, with power conversion efficiencies (PCE) up to 17.6 %.

    35. Inorganic Chemistry | Hot Paper

      Oxidation State 10 Exists (pages 9004–9006)

      Haoyu S. Yu and Prof. Donald G. Truhlar

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201604670

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      An existential conundrum: The stability of transition-metal compounds with a metal formal oxidation state of 10 was determined with Kohn–Sham density functional theory, and PtO42+ was found to be stable. PtO42+ reveals a similar electron density but a larger partial atomic charge on the metal when compared to IrO4+, for which the highest oxidation state of 9 was previously found.

    36. Asymmetric Catalysis

      Iridium-Catalyzed Enantioselective Hydroalkynylation of Enamides for the Synthesis of Homopropargyl Amides (pages 9007–9011)

      Xiao-Yan Bai, Zi-Xuan Wang and Prof. Dr. Bi-Jie Li

      Version of Record online: 25 APR 2016 | DOI: 10.1002/anie.201601792

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      Jockeying into position: The title reaction proceeds regioselectively with reaction at the β-position of an enamide, thus delivering homopropargyl amides. Good to high enantioselectivities were observed with an iridium complex ligated by the Ph-BPE ligand. This method provides a straightforward route to the synthesis of chiral homopropargyl amides with a stereocenter β to the amide. cod=1,5-cyclooctadiene, Tf=trifluoromethanesulfonyl.

    37. Carbon Dioxide Reduction

      Efficient Reduction of CO2 into Formic Acid on a Lead or Tin Electrode using an Ionic Liquid Catholyte Mixture (pages 9012–9016)

      Dr. Qinggong Zhu, Dr. Jun Ma, Xinchen Kang, Xiaofu Sun, Prof. Huizhen Liu, Jiayin Hu, Prof. Zhimin Liu and Prof. Buxing Han

      Version of Record online: 17 JUN 2016 | DOI: 10.1002/anie.201601974

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      Just a splash: Addition of a small amount of water to an ionic liquid/acetonitrile electrolyte mixture enhanced the efficiency of the electrochemical reduction of CO2 into formic acid significantly using a Pb or Sn electrode. The partial current density for HCOOH was as high as 37.6 mA cm−2 at a Faradaic efficiency of 91.6 %.

    38. Synthetic Biology | Hot Paper

      Short Self-Assembling Peptides Are Able to Bind to Copper and Activate Oxygen (pages 9017–9020)

      Dr. Olga V. Makhlynets, Pallavi M. Gosavi and Prof. Dr. Ivan V. Korendovych

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201602480

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      Let's get together: De novo designed peptides were developed that self-assemble in the presence of copper to create supramolecular assemblies that catalyze the oxidation of dimethoxyphenol in the presence of dioxygen. Formation of the supramolecular assembly, which is akin to a protein fold, is critical for productive catalysis since peptides possessing the same functional groups but lacking the ability to self-assemble do not catalyze substrate oxidation.

    39. Nanocrystals | Very Important Paper

      Excavated Cubic Platinum–Tin Alloy Nanocrystals Constructed from Ultrathin Nanosheets with Enhanced Electrocatalytic Activity (pages 9021–9025)

      Qiaoli Chen, Yanan Yang, Zhenming Cao, Dr. Qin Kuang, Guifen Du, Dr. Yaqi Jiang, Prof. Zhaoxiong Xie and Prof. Lansun Zheng

      Version of Record online: 21 JUN 2016 | DOI: 10.1002/anie.201602592

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      Excavated cubic Pt–Sn alloy nanocrystals with {110} facets were constructed by the assembly of ultrathin nanosheets by co-reduction in the presence of a surfactant. These nanocrystals have a very high surface area and displayed superior electrocatalytic activity towards methanol oxidation.

    40. Nanocomposite Catalysts

      Synthesis of α-MoC1−x Nanoparticles with a Surface-Modified SBA-15 Hard Template: Determination of Structure–Function Relationships in Acetic Acid Deoxygenation (pages 9026–9029)

      Dr. Frederick G. Baddour, Connor P. Nash, Dr. Joshua A. Schaidle and Dr. Daniel A. Ruddy

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/anie.201602878

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      A molybdenum-carbide and SBA-15 silica nanocomposite catalyst: A synthetic route was developed for direct growth of isolated α-MoC1−x nanoparticles in the pores of surface-modified SBA-15 silica. Compared to bulk carbides, the bifunctional nanocatalysts exhibit a greater acid-site:H-site ratio and a fraction of stronger acid sites, which influence catalytic selectivity during acetic acid hydrodeoxygenation.

    41. Ordered Nanoparticles | Hot Paper

      Ordered PdCu-Based Nanoparticles as Bifunctional Oxygen-Reduction and Ethanol-Oxidation Electrocatalysts (pages 9030–9035)

      Kezhu Jiang, Pengtang Wang, Prof. Shaojun Guo, Dr. Xu Zhang, Dr. Xuan Shen, Prof. Gang Lu, Dr. Dong Su and Prof. Xiaoqing Huang

      Version of Record online: 2 JUN 2016 | DOI: 10.1002/anie.201603022

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      Non-platinum electrocatalysts for fuel-cell reactions, composed of ordered intermetallic PdCuM nanoparticles (NPs; M=Ni or Co), have been synthesized. These ordered PdCuM NPs are generally much more active and stable than the conventional disordered counterparts and also the commercial Pt/C and Pd/C catalysts, towards both the ethanol-oxidation and oxygen-reduction reactions (ADTs=accelerated durability tests).

    42. Single-Molecule Detection

      Direct Measurement of Single-Molecule DNA Hybridization Dynamics with Single-Base Resolution (pages 9036–9040)

      Gen He, Jie Li, Haina Ci, Prof. Chuanmin Qi and Prof. Xuefeng Guo

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201603038

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      By using an electronic circuit on decorated silicon nanowires, the folding/unfolding process of individual hairpin DNAs were recorded. These measurements revealed current oscillations with strong temperature dependence, allowing determination of the thermodynamic and kinetic properties of hairpin DNA hybridization and the generation of a single-base pair kinetic zipper model for DNA hybridization.

    43. Amperometry

      Using Single-Cell Amperometry To Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis (pages 9041–9044)

      Dr. Xianchan Li, Johan Dunevall and Prof. Andrew G. Ewing

      Version of Record online: 30 MAY 2016 | DOI: 10.1002/anie.201602977

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      The pretreatment of PC12 cells with cisplatin influences the exocytotic ability of the cells in a dose-dependent manner. Single-cell amperometry experiments show that low concentrations of cisplatin stimulate catecholamine release whereas high concentrations inhibit this process.

    44. Synthetic Methods

      Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives (pages 9045–9049)

      Javier Miró, Dr. Carlos del Pozo, Prof. F. Dean Toste and Prof. Santos Fustero

      Version of Record online: 7 JUN 2016 | DOI: 10.1002/anie.201603046

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      Box in: A modular and step-economical method for the direct β,β-fluoroarylation of conjugated carbonyl derivatives is reported. This approach provides access to a range of enantioenriched β-fluorinated carbonyl derivatives in good yields. BOX=bis(oxazoline), PyrOX=pyridine oxazoline.

    45. Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide (pages 9050–9054)

      Jiansheng Zhu, Yafei Liu and Prof. Dr. Qilong Shen

      Version of Record online: 17 JUN 2016 | DOI: 10.1002/anie.201603166

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      A general method for the formation alkyl difluoromethylethers from the reaction of an alcohol with an electrophilic difluoromethylating reagent (1 a) is reported. The reaction conditions are mild and a variety of functional groups are compatible.

    46. Inorganic Nanotubes

      General Self-Template Synthesis of Transition-Metal Oxide and Chalcogenide Mesoporous Nanotubes with Enhanced Electrochemical Performances (pages 9055–9059)

      Huan Wang, Sifei Zhuo, Yu Liang, Xiling Han and Prof. Bin Zhang

      Version of Record online: 30 MAY 2016 | DOI: 10.1002/anie.201603197

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      Down to the wire: A facile thermal oxidation-induced transformation using cheap metal–organic coordination nanowires as starting precursors is the basis of the synthesis of inorganic nanotubes with open-ended channels and mesoporous walls. The nanotubes exhibit excellent performances in the electrocatalytic oxygen evolution reaction and for rechargeable lithium-ion batteries.

    47. Amides

      Sterically Demanding Oxidative Amidation of α-Substituted Malononitriles with Amines Using O2 (pages 9060–9064)

      Jing Li, Dr. Martin J. Lear and Prof. Dr. Yujiro Hayashi

      Version of Record online: 14 JUN 2016 | DOI: 10.1002/anie.201603399

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      Mix and stir: With just O2 and base, the direct coupling of readily available malononitriles and amines provides an efficient way to make sterically hindered amides. A radical mechanism involving dioxirane intermediates is proposed, and is supported by cyclopropane-based radical-clock experiments.

    48. Enantioselectivity

      Enantio- and Diastereoselective 1,2-Additions to α-Ketoesters with Diborylmethane and Substituted 1,1-Diborylalkanes (pages 9065–9069)

      Stephanie A. Murray, Jacob C. Green, Sanita B. Tailor and Prof. Simon J. Meek

      Version of Record online: 20 JUN 2016 | DOI: 10.1002/anie.201603465

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      Catalytic enantioselective synthesis of boronate-substituted tertiary alcohols is possible through the title reaction. The reactions are catalyzed by chiral phosphine/copper(I) complexes and produce β-hydroxyboronates containing up to two contiguous stereogenic centers. The utility of the organoboron products is demonstrated through several chemoselective functionalizations. pin=pinacolato, TMS=trimethylsilyl.

    49. Metal–Organic Frameworks

      You have full text access to this OnlineOpen article
      Fulleretic Well-Defined Scaffolds: Donor–Fullerene Alignment Through Metal Coordination and Its Effect on Photophysics (pages 9070–9074)

      Derek E. Williams, Ekaterina A. Dolgopolova, Danielle C. Godfrey, Evgeniya D. Ermolaeva, Dr. Perry J. Pellechia, Prof. Dr. Andrew B. Greytak, Dr. Mark D. Smith, Dr. Stanislav M. Avdoshenko, Dr. Alexey A. Popov and Prof. Dr. Natalia B. Shustova

      Version of Record online: 6 JUN 2016 | DOI: 10.1002/anie.201603584

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      Photophysics: In a crystalline metal–donor–fullerene framework the donor–fullerene mutual orientation is controlled through metal coordination. Because of ultrafast energy and electron transfer, fulleretic materials will contribute not only to the basic science of fullerene chemistry, but also be used for developments in photovoltaics and molecular electronics.

    50. Crystal Growth | Hot Paper

      Determination of the Preassembled Nucleating Units That Are Critical for the Crystal Growth of the Metal–Organic Framework CdIF-4 (pages 9075–9079)

      Raghidah Wagia, Dr. Ilya Strashnov, Prof. Michael W. Anderson and Dr. Martin P. Attfield

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201603687

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      Growth agents: Through the combined use of in situ atomic force microscopy and mass spectrometry, several preformed cadmium-containing species that are present in the growth solution of the cadmium 2-ethylimidazolate metal–organic framework CdIF-4 were identified. Their presence was shown to be critical for surface nucleation.

    51. Synthetic Methods

      Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates (pages 9080–9083)

      Ming-Hsiu Yang, Jordan R. Hunt, Dr. Niusha Sharifi and Prof. Dr. Ryan A. Altman

      Version of Record online: 17 JUN 2016 | DOI: 10.1002/anie.201604149

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      Alkylation reactions of α,α-difluoroketone enolates with sp3-based electrophiles have been underdeveloped because of intrinsically weak nucleophilicity and chemoselective formation associated with this enolate. Reported herein is a palladium-catalyzed decarboxylative benzylation of α,α-difluoroketone enolates, in which the external α,α-difluoroenolate, formed in situ, underwent reductive elimination from a palladium(II) intermediate to generate the key C(α)−C(sp3) bond.

    52. C−H Activation | Hot Paper

      Catalytic C(sp3)−H Arylation of Free Primary Amines with an exo Directing Group Generated In Situ (pages 9084–9087)

      Yan Xu, Dr. Michael C. Young, Chengpeng Wang, David M. Magness and Prof. Guangbin Dong

      Version of Record online: 8 JUN 2016 | DOI: 10.1002/anie.201604268

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      The direct arylation of unactivated aliphatic C−H bonds in free primary amines was achieved by using an exo-imine-type directing group (DG) that can be generated and removed in situ. Both primary aliphatic amines and anilines are suitable substrates, and methyl as well as cyclic and acyclic methylene groups smoothly underwent site-selective arylation.

    53. Heterocycle Synthesis

      Gold(I)-Catalyzed N-Desulfonylative Amination versus N-to-O 1,5-Sulfonyl Migration: A Versatile Approach to 1-Azabicycloalkanes (pages 9088–9092)

      Solène Miaskiewicz, Boris Gaillard, Dr. Nicolas Kern, Prof. Dr. Jean-Marc Weibel, Prof. Dr. Patrick Pale and Dr. Aurélien Blanc

      Version of Record online: 16 JUN 2016 | DOI: 10.1002/anie.201604329

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      Worth their weight in gold: The great value of sulfonamides in gold catalysis is highlighted by two hydroamination reactions that occur by migration or cleavage of sulfonyl group (see scheme). These unprecedented gold-promoted sulfonyl-transfer reactions open the way to appealing synthetic applications of these robust nitrogen-protecting groups, as demonstrated by the formation of versatile azabicycles.

    54. Superhydrophilic Surfaces

      One-Step Assembly of Phytic Acid Metal Complexes for Superhydrophilic Coatings (pages 9093–9096)

      Longbiao Li, Guangyu Zhang and Prof. Zhaohui Su

      Version of Record online: 5 JUL 2016 | DOI: 10.1002/anie.201604671

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      Wet, wet, wet: Natural phytic acid reacts with FeIII ions to produce rough coatings of coordination complexes in one step to make a variety of substrates superhydrophilic. Coating deposition occurs in minutes. The coatings are ultrathin, colorless, transparent, and suitable for a range of applications, such as oil/water separation and antifogging.

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