Changes in the metaphysis and diaphysis of the femur proximal to the knee in rabbits with experimentally induced inflammatory arthritis

Authors

  • E. Bogoch MD, MSc, FRCS(C),

    Assistant Professor, Corresponding author
    1. Department of Surgery, University of Toronto, and The Wellesley Hospital, Toronto, Ontario, Canada
    • The Wellesley Hospital, 160 Wellesley Street E, Toronto, Ontario M4Y 1J3, Canada
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    • Recipient of fellowships from the Samuel B. McLaughlin Foundation and the Ewart Angus Foundation, Toronto

  • N. Gschwend MD,

    Chief Surgeon
    1. Klinik Wilhelm Schulthess, Zurich, Switzerland; and the Swiss Research Institute, Davos, Switzerland
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  • B. Bogoch DIPN, LLB,

    1. Department of Surgery, University of Toronto, and The Wellesley Hospital, Toronto, Ontario, Canada
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  • B. Rahn MD,

    Director
    1. Klinik Wilhelm Schulthess, Zurich, Switzerland; and the Swiss Research Institute, Davos, Switzerland
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  • S. Perren MD

    Director
    1. Klinik Wilhelm Schulthess, Zurich, Switzerland; and the Swiss Research Institute, Davos, Switzerland
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Abstract

We quantified the cross-sectional cortical bone area and remodeling rates in the ipsilateral femoral diaphysis and metaphysis of rabbits with carrageenan-induced inflammatory monarthritis of the knee. Although osteogenesis rates were significantly elevated (approximately threefold in diaphyses and sixfold in metaphyses), the cross-sectional bone area of the diaphysis was significantly diminished. Fivefold and sixfold increases in bone resorption rates were calculated in diaphyses and metaphyses, respectively. Other morphologic changes observed were porosity and net resorption of the anterior cortex and net accretion on the posteromedial cortex (“drift” of bone). These findings may have clinical significance with regard to the mechanisms and consequences of bone changes in patients with rheumatoid arthritis.

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