Speciation Analysis and Environment

Simultaneous determination of degradation products related to chemical warfare agents by high-performance liquid chromatography/mass spectrometry†

  1. Takeharu Wada*,
  2. Eiko Nagasawa,
  3. Shigeyuki Hanaoka

Article first published online: 20 JUL 2006

DOI: 10.1002/aoc.1109

Issue

Applied Organometallic Chemistry

Applied Organometallic Chemistry

Special Issue: Special issue including information from the 12th Symposium of the Japanese Arsenic Scientists' Society (JASS) held 5–6 November 2005 in Takizawa, Iwate Prefecture, Japan

Volume 20, Issue 9, pages 573–579, September 2006

Additional Information

How to Cite

Wada, T., Nagasawa, E. and Hanaoka, S. (2006), Simultaneous determination of degradation products related to chemical warfare agents by high-performance liquid chromatography/mass spectrometry. Appl. Organometal. Chem., 20: 573–579. doi: 10.1002/aoc.1109

Author Information

  1. Chemicals Evaluation and Research Institute, Japan, Tokyo Laboratory, Environmental Technology Department, 1600 Shimotakano, Sugito-machi, Kitakatsushika-gun, Saitama 345-0043, Japan

*Tokyo Laboratory, Chemicals Evaluation and Research Institute, Japan, 1600, Shimotakano, Sugito-machi, Kikakatsushika-gun, Saitama, 345-0043, Japan.

  1. †

    This paper is based on work presented at the 12th Symposium of the Japanese Arsenic Scientists' Society (JASS) held 5–6 November 2005 in Takizawa, Iwate Prefecture, Japan. E-mail: yamaoka-yu@aist.go.jp

Publication History

  1. Issue published online: 17 AUG 2006
  2. Article first published online: 20 JUL 2006
  3. Manuscript Accepted: 15 MAY 2006
  4. Manuscript Received: 1 MAY 2006

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Keywords:

  • chemical warfare agents;
  • organoarsenic compounds;
  • degradation products;
  • Lewisite oxide;
  • Diphenylarsinic acid;
  • LC/MS/MS

Abstract

Chemical munitions that include organoarsenic chemical agent were manufactured by Japanese imperial forces and abandoned in various locations of Japan and China at the end of World War II. These organoarsenic compounds and various decomposition products have caused environmental contamination and damage to health. For the analysis of chemical warfare agents (CWA) and related compounds in environmental samples, determination was carried out using high-performance liquid chromatography/tandem mass spectrometry of nine CWA-related compounds: 2-chlorovinylarsonic acid (CVAOA), phenylarsonic acid (PAA), thiodigricol (TDG), phenylmethlarsinic acid (PMAA), 2-chlorovinylarsine oxide (CVAO), phenylarsine oxide (PAO), diphenylarsenic acid (DPAA), bis(2-chlorovinyl)arsinous acid (BCVAA) and bis(diphenylarsine)oxide (BDPAO). TDG and eight arsine compounds could be simultaneously measured by LC/MS/MS equipped with a reversed-phase column (C8). The limits of detection of CVAOA, PAA, PMAA, DPAA and other compounds were 0.5, 0.05, 0.001, 0.0001 and 0.01 µg/ml, respectively. Copyright © 2006 John Wiley & Sons, Ltd.

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