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Keywords:

  • nanoparticles;
  • magnetosomes;
  • magnetic fluids;
  • iron oxide;
  • organosilicon compounds;
  • alkanolamines;
  • drug research;
  • cytotoxicity

Abstract

New original water-soluble magnetic nanoparticles based on natural components, magnetite–oleic acid–biologically active silyl modified alkanolamine, were synthesized. Physico-chemical characterization, i.e. magnetic properties, concentration of magnetite, size of iron oxide core, of the nanoparticles synthesized and the corresponding magnetic fluids obtained, was carried out. Magnetic fluids were screened for in vitro cytotoxicity concerning human fibrosarcoma (HT-1080), mouse hepatoma (MG-22A) monolayer tumour cell lines and normal mouse fibroblasts (NIH 3T3). They possess low or moderate cytotoxic effects, are non-toxic, exhibit high NO-induction ability and strongly change tumour cell morphology. Copyright © 2008 John Wiley & Sons, Ltd.