Efficient synthesis of conjugated alkynyl cycloalkenones: Pd(PPh3)4–AgOAc- catalyzed direct coupling of 1-alkynes with 3-oxocycloalkenyl triflates



Palladium—silver acetate-catalyzed cross coupling of vinyl triflates and 1-alkynes was investigated. This strategy offered a very straightforward and efficient method for access to conjugated alkynyl cycloalkenones from the conjugated vinyl triflates and 1-alkynes. Moreover, the triflates derived from 1,3-cycloalkadione needed no further purification and could be reacted immediately with 1-alkynes to provide the conjugated alkynyl cycloalkenones in excellent overall yields. Copyright © 2009 John Wiley & Sons, Ltd.