Get access

Release of ibuprofen from poly(ε-caprolactone-co-D,L-lactide) and simulation of the release

Authors

  • Niina Ahola,

    1. Helsinki University of Technology, Department of Chemical Technology, Polymer Technology, P.O. Box 6100, FIN-02015 HUT, Finland
    Search for more papers by this author
  • Jaana Rich,

    1. Helsinki University of Technology, Department of Chemical Technology, Polymer Technology, P.O. Box 6100, FIN-02015 HUT, Finland
    Search for more papers by this author
  • Teija Karjalainen,

    1. Helsinki University of Technology, Department of Chemical Technology, Polymer Technology, P.O. Box 6100, FIN-02015 HUT, Finland
    Search for more papers by this author
  • Jukka Seppälä

    Corresponding author
    1. Helsinki University of Technology, Department of Chemical Technology, Polymer Technology, P.O. Box 6100, FIN-02015 HUT, Finland
    • Helsinki University of Technology, Department of Chemical Technology, Polymer Technology, P.O. Box 6100, FIN-02015 HUT, Finland
    Search for more papers by this author

Abstract

A study was made of the effects of the initial ibuprofen load and of the specimen shape on the release of ibuprofen from poly(ε-caprolactone-co-D,L-lactide). The mol ratio of the comonomers in the copolymer was 96/4 (caprolactone to lactide) and the experiments were conducted at 37°C in vitro. The results showed that release of ibuprofen is fast and that the rate and profile of the release vary with both the initial load of ibuprofen and the shape of the specimen. The rate of ibuprofen release increases with the initial load and with the surface area-to-volume ratio of the specimen, obeying Fickian diffusion. The experimental findings were compared with the results of a mathematical simulation model based on the finite-difference method. Diffusion parameters needed for the simulation were determined from a separately conducted set of experiments using various methods. For the most part, the results of the simulations and the experiments were in good agreement. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 1279–1288, 2003

Ancillary