Stability and depolymerization of poly(sebacic anhydride) under high moisture environment



Polyanhydrides are found to be useful in drug delivery systems; however, these aliphatic polyanhydrides are also unstable under humidity and temperature (greater than 0°C) for their low toxicity and surface eroding mode of drug release. In this research, poly(sebacic anhydride) was synthesized for a stability and depolymerization study in high humidity a surrounding temperature of 35°C. According to the results from gel permeation chromatography, IR spectrophotometry, and differential scanning calorimetry investigations, it was found that both self-depolymerization and hydrolysis mechanisms existed during the depolymerization process for poly(sebacic anhydride) and they can be monitored directly. These results were further compared with previous research in a depolymerization study of polyanhydrides in a vacuum and in buffer solution. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 1423–1429, 2003