The dialysis of non-electrolytes through regenerated cellulose (Cuprophan). I. The effect of molecular size

Authors

  • S. Bottomley,

    1. Biochemistry Department, Coventry and Warwickshire Hospital, Coventry, Renal Research Unit, The General Infirmary at Leeds, and Department of Chemical Pathology, University of Leeds, England
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  • F. M. Parsons,

    1. Biochemistry Department, Coventry and Warwickshire Hospital, Coventry, Renal Research Unit, The General Infirmary at Leeds, and Department of Chemical Pathology, University of Leeds, England
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  • P. M. G. Broughton

    1. Biochemistry Department, Coventry and Warwickshire Hospital, Coventry, Renal Research Unit, The General Infirmary at Leeds, and Department of Chemical Pathology, University of Leeds, England
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Abstract

Solutions of single solutes were dialyzed through Cuprophan using a modified Muir-Ross cell and their half-clearance times were measured. A linear relationship was found between half-clearance time and molecular cross-sectional area for solutes with molecular weights between 60 and 1134. The size of the largest molecule which will dialyze through Cuprophan probably has a molecular weight of about 18,000.

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