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The dialysis of non-electrolytes through regenerated cellulose (Cuprophan). II. The dialysis of binary mixtures

Authors

  • S. Bottomley,

    1. Biochemistry Department, Coventry and Warwickshire Hospital, Conventry, Renal Research Unit, The General Infirmary at Leeds, and Department of Chemical Pathology, University of Leeds, England
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  • F. M. Parsons,

    1. Biochemistry Department, Coventry and Warwickshire Hospital, Conventry, Renal Research Unit, The General Infirmary at Leeds, and Department of Chemical Pathology, University of Leeds, England
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  • P. M. G. Broughton

    1. Biochemistry Department, Coventry and Warwickshire Hospital, Conventry, Renal Research Unit, The General Infirmary at Leeds, and Department of Chemical Pathology, University of Leeds, England
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Abstract

Solutions containing two organic compounds of different concentrations were dialyzed through Cuprophan using a modified Muir-Ross cell. The dialysis rate of the solute present in a low concentration (hypoconcentrate) was altered by the presence of a large concentration of a second solute (hyperconcentrate). The effect was unrelated to the molecular radius of the hyperconcentrate or, for acids and bases, to the dissociation constant. It was related, though not proportionately, to the solubility (expressed in mole/1.) of the hyperconcentrate. It is postulated that the effect is due to changes in the hydrogenbonded structure of the water induced by the dissolution of solutes in this solvent.

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