Prediction of sedimentation coefficients of random coil polymers



The concentration dependence of the radius of gyration and the equivalent hydrodynamic radius of polymers in solution is described well by a model developed in earlier work. The calculated hydrodynamic volumes of solvated polymers are combined with the statistical mechanical calculations of Burgers for hard spheres to predict sedimentation coefficients at finite concentrations. The predicted values are in good agreement with experimental results.