Synthesis of bioactive 2,2-dichloropropionic acid esters of carboxymethyl cellulose and investigations on their release behavior



Polymer bound bioactive agents are prepared by linking 2,2-dichloropropionic acid to the hydroxyl groups of carboxymethyl cellulose (CMC) and enzymatically cleavable CMC networks, and to the carboxyl groups of CMC via enzymatically cleavable spacer units using a simple as well as effective CMC activation procedure. The hydrolytic release of the bioactive agent is mainly dependent on the hydrophilicity of the CMC esters. In the case of polymers containing enzymatically cleavable structural units the release can be accelerated by addition of esterases.