Inhibition of bovine serum albumin adsorption by poly(ethylene glycol) soft segment in biodegradable poly(ethylene glycol)/poly(L-lactide) copolymers
Article first published online: 10 MAR 2003
Copyright © 1993 John Wiley & Sons, Inc.
Journal of Applied Polymer Science
Volume 50, Issue 8, pages 1391–1396, 20 November 1993
How to Cite
Hu, D. S.-G., Liu, H.-J. and Pan, I.-L. (1993), Inhibition of bovine serum albumin adsorption by poly(ethylene glycol) soft segment in biodegradable poly(ethylene glycol)/poly(L-lactide) copolymers. J. Appl. Polym. Sci., 50: 1391–1396. doi: 10.1002/app.1993.070500810
- Issue published online: 10 MAR 2003
- Article first published online: 10 MAR 2003
- Manuscript Accepted: 5 JAN 1993
- Manuscript Received: 9 SEP 1992
The objective of this study was to investigate the effects of the incorporation of ether linkages into polylactide (PLLA) chains and the time of biodegradation on the behavior of protein adsorption. The content of poly(ethylene glycol) (PEG) in PLLA/PEG copolymers is from 4.4 to 18.3 wt %, and the length of the PEG soft segment is 1000, 2000, and 6000 daltons. The bovine serum albumin (BSA) adsorption onto the biodegradable PLLA/PEG copolymers was carried out using ultraviolet spectroscopy. The surface tension of PLLA and PLLA/PEG was measured using a contact angle. The data show that the incorporation of PEG segments makes the copolymer more polar and, therefore, leads to a reduction of protein adsorption. As the hydrolysis of polymers proceeds, both PLLA and PLLA/PEG turn out to be more polar. However, the initial compositions of degraded PLLA/PEG have a weak influence on the protein adsorption onto its hydrolyzed surface with a substantially long duration of hydrolysis. This phenomenon is attributed to the hydrophobic interaction between polar PLLA/PEG and BSA. © 1993 John Wiley & Sons, Inc.