Ozone-induced grafting of a sulfoammonium zwitterionic polymer onto low-density polyethylene film for improving hemocompatibility

Authors

  • Bing Shan,

    1. Center of Research on Surface and Interface Chemical Engineering and Technology, Nangjing University, Nanjing, 210093, People's Republic of China
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  • Han Yan,

    1. Center of Research on Surface and Interface Chemical Engineering and Technology, Nangjing University, Nanjing, 210093, People's Republic of China
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  • Jian Shen,

    1. Center of Research on Surface and Interface Chemical Engineering and Technology, Nangjing University, Nanjing, 210093, People's Republic of China
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  • Sicong Lin

    Corresponding author
    1. Center of Research on Surface and Interface Chemical Engineering and Technology, Nangjing University, Nanjing, 210093, People's Republic of China
    • Center of Research on Surface and Interface Chemical Engineering and Technology, Nangjing University, Nanjing, 210093, People's Republic of China
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Abstract

Ozone-induced grafting was developed to improve the hemocompatibility of biomaterials based on low-density polyethylene (LDPE). An LDPE film was activated with ozone and graft-polymerized with N,N′-dimethyl(methacryloylethyl)ammonium propane sulfonate (DMAPS). The existence of sulfobetaine structures on the grafted film was confirmed by X-ray photoelectron spectroscopy and attenuated total reflection/Fourier transform infrared (ATR–FTIR). More DMAPS was grafted onto the LDPE film as the DMAPS concentration increased, as determined by ATR–FTIR. Static contact-angle measurements indicated that the DMAPS-grafted LDPE film had a significant increase in hydrophilicity. The blood compatibility of the grafted film was preliminarily evaluated with a platelet-rich-plasma (PRP) adhesion study. No platelet adhesion was observed on the grafted film incubated with PRP at 37°C for 180 min. This new sulfoammonium zwitterionic-structure-grafted biomaterial might have potential for biomedical applications. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 3697–3703, 2006

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