Bioengineering functional copolymers: V. Synthesis, LCST, and thermal behavior of poly(N-isopropyl acrylamide-co-p-vinylphenylboronic acid)

Authors

  • E. K. Çimen,

    1. Department of Chemical Engineering and Division of Bioengineering, Faculty of Engineering, Hacettepe University, Beytepe, 06532 Ankara, Turkey
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  • Zakir M. O. Rzaev,

    Corresponding author
    1. Department of Chemical Engineering and Division of Bioengineering, Faculty of Engineering, Hacettepe University, Beytepe, 06532 Ankara, Turkey
    • Department of Chemical Engineering and Division of Bioengineering, Faculty of Engineering, Hacettepe University, Beytepe, 06532 Ankara, Turkey
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  • E. Pişkin

    1. Department of Chemical Engineering and Division of Bioengineering, Faculty of Engineering, Hacettepe University, Beytepe, 06532 Ankara, Turkey
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Abstract

New boron-containing stimuli-responsive (pH- and temperature-sensitive) copolymers were synthesized and characterized. Structure and composition of copolymers were determined by FTIR and 1H-NMR spectroscopy, and elemental analysis and titration (N and B contents for NIPA and VPBA unit, respectively). By DSC and XRD measurements, it is established that the synthesized copolymers have a semicrystalline structure due to formation of intra- and/or intermolecular H-bonded supramolecular architecture. The copolymer composition–structure–property relationship indicates semicrystalline structure of copolymers with different compositions, degrees of crystallinity, and thermal and stimuli-responsive behaviors depends on the content of boron-containing monomer linkage. Results of DSC, DTA, and TGA analyses indicated that copolymers have Tg and Tm and high thermal stability. These water-soluble and temperature- and pH-sensitive amphiphilic copolymers can be used as polymeric carries for delivery of biological entities for diverse biomedical use, including boron neutron capture therapy. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 573–582, 2005

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