Self-assembly and drug delivery behaviors of thermo-sensitive poly(t-butyl acrylate)-b-poly(N-isopropylacrylamide) micelles

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Abstract

Self-assembly of thermo-sensitive poly (t-butyl acrylate)-b-poly(N-isopropylacrylamide) (PtBA- b-PNIPAM) micelles in aqueous medium and its applications in controlled release of hydrophobic drugs were described. PtBA-b-PNIPAM was synthesized by atom transfer radical polymerization and aggregated into thermo-sensitive core-shell micelles with regular spheres in water, which was confirmed by 1H-NMR, fluorescence spectroscopy, transmission electron microscopic (TEM), and UV–vis spectroscopic techniques. The critical micelle concentration of micelles decreased with the increase of the hydrophobic components. The anti-inflammation drug naproxen (NAP) was loaded as the model drug into polymeric micelles, which showed a dramatic thermo-sensitive fast/slow switching behavior around the lower critical solution temperature (LCST). When the temperature was enhanced above LCST, release of NAP from core-shell micelles was accelerated ascribed to the temperature-induced deformation of micelles. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009

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