Synthesis and application of CDA-beta-CD in controlling release of drug



To chemically attach beta-cyclodextrin (beta-CD) molecules to cellulose diacetate (CDA), an isocyanate containing preformed polymer was synthesized by prepolymerization of CDA and toluene-2,4-diisocyanate (TDI), which was then grafted with beta-CD. Effects of reaction temperature, time, and mixture ratio on reactions were observed. The structure of CDA-beta-CD was characterized by 1H- and 13C-NMR spectra; the release of CDA-beta-CD with medicament naproxen by dynamic dialysis in the artificial simulated intestinal fluid (pH = 7.4) was studied in vitro. Results indicated that the release time could reach more than 8 h at a graft ratio of 68.7%, which showed a good controlled-release drug effect. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009