To chemically attach beta-cyclodextrin (beta-CD) molecules to cellulose diacetate (CDA), an isocyanate containing preformed polymer was synthesized by prepolymerization of CDA and toluene-2,4-diisocyanate (TDI), which was then grafted with beta-CD. Effects of reaction temperature, time, and mixture ratio on reactions were observed. The structure of CDA-beta-CD was characterized by 1H- and 13C-NMR spectra; the release of CDA-beta-CD with medicament naproxen by dynamic dialysis in the artificial simulated intestinal fluid (pH = 7.4) was studied in vitro. Results indicated that the release time could reach more than 8 h at a graft ratio of 68.7%, which showed a good controlled-release drug effect. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.