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Keywords:

  • alginate microspheres;
  • crosslinking;
  • emulsification;
  • fluorescence;
  • magnetic nanoparticles

Abstract

Composite alginate microspheres were synthesized via a modified emulsification technique and characterized by inverted optical microscope, transmission electron microscope, ζ-potential analyzer, UV–vis spectrophotometer, luminescence spectrometer, and vibrating sample magnetometer. The results show that the synthetic parameters including the weight ratio of maghemite nanoparticles to alginate, hydrophile-lipophile balance (HLB) value, stirring speed, and CaCl2 dripping rate play important roles in the synthesis of microspheres. Furthermore, the composite alginate microspheres exhibit good superparamagnetism and fluorescence, which can serve both as magnetic resonance contrast agents and optical probes for biological imaging. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009