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Synthesis, characterization, and application of composite alginate microspheres with magnetic and fluorescent functionalities

Authors

  • Jiwei Liu,

    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
    2. School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China
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  • Yu Zhang,

    Corresponding author
    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
    • State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
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  • Ting Yang,

    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
    2. School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China
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  • Yuqing Ge,

    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
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  • Song Zhang,

    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
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  • Zhongping Chen,

    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
    2. School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China
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  • Ning Gu

    Corresponding author
    1. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
    • State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, People's Republic of China
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Abstract

Composite alginate microspheres were synthesized via a modified emulsification technique and characterized by inverted optical microscope, transmission electron microscope, ζ-potential analyzer, UV–vis spectrophotometer, luminescence spectrometer, and vibrating sample magnetometer. The results show that the synthetic parameters including the weight ratio of maghemite nanoparticles to alginate, hydrophile-lipophile balance (HLB) value, stirring speed, and CaCl2 dripping rate play important roles in the synthesis of microspheres. Furthermore, the composite alginate microspheres exhibit good superparamagnetism and fluorescence, which can serve both as magnetic resonance contrast agents and optical probes for biological imaging. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009

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