Get access

Incorporation of triclosan into polydioxanone monofilaments and evaluation of the corresponding release

Authors

  • M. G. Blanco,

    1. Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria Industrial, Universitat Politècnica de Catalunya, Diagonal 647, Barcelona E-08028, Spain
    Search for more papers by this author
  • L. Franco,

    1. Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria Industrial, Universitat Politècnica de Catalunya, Diagonal 647, Barcelona E-08028, Spain
    Search for more papers by this author
  • J. Puiggalí,

    1. Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria Industrial, Universitat Politècnica de Catalunya, Diagonal 647, Barcelona E-08028, Spain
    Search for more papers by this author
  • A. Rodríguez-Galán

    Corresponding author
    1. Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria Industrial, Universitat Politècnica de Catalunya, Diagonal 647, Barcelona E-08028, Spain
    • Departament d'Enginyeria Química, Escola Tècnica Superior d'Enginyeria Industrial, Universitat Politècnica de Catalunya, Diagonal 647, Barcelona E-08028, Spain
    Search for more papers by this author

Abstract

Poly(p-dioxanone) monofilaments were loaded with triclosan, a drug with a well-known antimicrobial effect. Two different procedures were considered: loading by molecular diffusion with a swelling solvent such as dichloromethane and loading by means of a coating based on polycaprolactone or polycaprolactone/magnesium stearate mixtures. Triclosan release was studied in different media by high-performance liquid chromatography. The kinetics of loading by diffusion and the release from both kinds of preparations were evaluated with well-established models. In general, the first stages of the loading process fit with the Higuchi approximation, whereas the final stages fit with the first-order model. The last model could be applied to predict the release behavior. A sustained release over a period that could reach 400 h was attained when ethanol was added to the release medium, whereas equilibrium conditions were reached when Sörensen's hydrophilic medium was used. Significant differences in the release profiles of a Sörensen's/ethanol medium were observed, which depended on the loading methodology. Thus, an 80% release was attained after 36 h for a polycaprolactone-coated sample and after 80–100 h for a sample loaded by diffusion. Degradation studies of the triclosan-loaded samples were also performed because the increase in the hydrophobicity of the samples could hinder the hydrolytic degradation. The weight-average molecular weight of unloaded and loaded (29,075 μg/g) sutures dropped to 220.000 and 110.000 after 45 days of exposure to the medium at 37°C, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009

Ancillary