Controlled release of carbamazepine from carboxymethyl chitosan-grafted- 2-hydroxyethylmethacrylate matrix tablets



The aim of the study was to prepare the controlled release dosage of carbamazepine matrix tablets using wet granulation technique. The graft copolymerization of carboxymethyl chitosan (CMCH) with 2-hydroxyethylmethacrylate (HEMA) was carried out. The product was characterized by Fourier-transform infrared, scanning electron microscopy, transmission electron micrograph, and X-ray diffraction anayses. CMCH-g-HEMA was used as binder to prepare the matrix tablets containing carbamazepine. The properties of tablets like hardness, friability, and dissolution influenced by binder were studied. In vitro release of the matrix tablets was carried out with the phosphate-buffered solution (pH 7.4) at 37°C and 100 × g using USP dissolution test apparatus. Release rate of carbamazepine from controlled release matrix tablets was compared with the commercially marketed tablet, Tagretol 200. Results show that after 6 hrs percentage drug release of formulated tablet CGH5 was 20.42% and that of Tegretol 200 was 18.32%. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010