Synthesis and evaluation of chitosan-vitamin C complexes

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Abstract

Chitosan (CS) is a biocompatible, biodegradable, and nontoxic polysaccharide polymer. It dissolves in water only if the pH is lower than 6.5. To extend its range of application, many water-soluble derivatives have, therefore, been prepared. In this research, chitosan-vitamin C complexes (CSVC) were synthesized and characterized with FTIR, DSC, and 1H-NMR. The solubility of CSVC in distilled water was greatly improved. The •O2- scavenging activity of CSVC was compared with CS and vitamin C (VC) by measuring the auto-oxidation rate of pyrogallic acid. Results showed that the scavenging activity on •O2 by CSVC was stronger than that by CS. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009

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