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Ferulic acid as a comonomer in the synthesis of a novel polymeric chain with biological properties

Authors

  • Francesca Iemma,

    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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  • Francesco Puoci,

    Corresponding author
    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
    • Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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  • Manuela Curcio,

    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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  • Ortensia I. Parisi,

    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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  • Giuseppe Cirillo,

    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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  • Umile G. Spizzirri,

    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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  • Nevio Picci

    1. Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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Abstract

In this study, ferulic acid was copolymerized with methacrylic acid to obtain a useful material with both antioxidant and antifungal properties. An ascorbic acid/hydrogen peroxide redox pair was used as a water-soluble and biocompatible initiator system to prime the one-pot polymerization reaction. The obtained material was characterized with gel permeation chromatography, Fourier transform infrared spectroscopy, ultraviolet spectroscopy, and fluorescence analyses, and the disposable phenolic group content was determined to verify the insertion of ferulic acid into the polymeric backbone. Finally, the antioxidant and antifungal activities were demonstrated toward the hydroxyl radical and Aspergillus niger, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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