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Synthesis and characterization of amphiphilic pluronic (F68)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymers and their micelles as a drug carrier

Authors

  • Tiewei Wang,

    1. National Center for Nanoscience and Technology, Department of Manomedicine and Nanobiology, Beijing 100190, China
    2. China Agricultural University, Department of Chemistry, Beijing 100083, China
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  • Yan Wu,

    Corresponding author
    1. National Center for Nanoscience and Technology, Department of Manomedicine and Nanobiology, Beijing 100190, China
    • National Center for Nanoscience and Technology, Beijing 100190, China
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  • Ai Jun Zeng

    1. China Agricultural University, Department of Chemistry, Beijing 100083, China
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Abstract

A new Pluronic (F68)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) (Pluronic (F68)–DPPE) copolymer was synthesized with Pluronic (F68) and DPPE. The chemical structure and physical properties of copolymers were determined by FTIR, 1H NMR, 13C NMR, 31P NMR, and TGA. Environmental scanning electron microscopy, fluorescence spectroscopy, and dynamic light scattering method confirmed the formation of copolymeric micelles of Pluronic (F68)-DPPE. To estimate the feasibility as novel drug carriers, the copolymer micelles were prepared by the phase separation dialysis method. Amphotericin B as a lipophilic model drug was incorporated into copolymeric micelles and the drug release behavior was investigated. It was found that the chemical composition of the micelle was a key factor in controlling micelles size, drug-loading content, and drug release behavior. As DPPE segment weight ratio increased, the micelle size and drug-loading content increased, and the drug release rate decreased. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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