This article is a US government work and, as such, is in the public domain in the United State of America.
Poly(lactic acid) membranes containing bacteriocins and EDTA for inhibition of the surface growth of gram-negative bacteria†
Article first published online: 18 MAR 2010
Copyright © 2010 Wiley Periodicals, Inc.
Journal of Applied Polymer Science
Volume 117, Issue 1, pages 486–492, 5 July 2010
How to Cite
Liu, L., Jin, T., Coffin, D. R., Liu, C.-K. and Hicks, K. B. (2010), Poly(lactic acid) membranes containing bacteriocins and EDTA for inhibition of the surface growth of gram-negative bacteria. J. Appl. Polym. Sci., 117: 486–492. doi: 10.1002/app.31550
- Issue published online: 30 MAR 2010
- Article first published online: 18 MAR 2010
- Manuscript Accepted: 4 OCT 2009
- Manuscript Received: 14 AUG 2009
- poly(lactic acid);
- synergetic activity;
- active packaging;
Films containing antibacterial reagents, ethylenediamine-tetraacetic acid disodium salt (EDTA) and Nisaplin®, were produced by coextrusion with poly(lactic acid) in the presence of a pharmaceutical grade glycerol triacetate. The incorporation of EDTA-Nisaplin® particles resulted in a heterogeneous biphasic structure, as revealed by scanning electronic microscopy, confocal laser microscopy, and acoustic emission tests. The inclusion of glycerol triacetate reduced the Young's modulus and tensile strength, while enhancing the flexibility and the toughness of the resulting blends. The inclusion of the plasticizer also allowed the extrusion to occur at a temperature as low as 120°C to maintain the biological activity of Nisaplin®, which in combination with EDTA, plays a synergistic effect on suppression of the growth of the Gram-negative bacteria, E. coli O157:H7. The films thus obtained show potential as packaging materials with a wide spectrum of antimicrobial activity. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010