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Nanogels of poly(acrylic acid): Uptake and release behavior with fluorescent oligothiophene-labeled bovine serum albumin

Authors

  • Simona Argentiere,

    1. National Nanotechnology Laboratories of CNR-INFM, Via Arnesano 16, Lecce I-73100, Italy
    2. Istituto Superiore Universitario di Formazione Interdisciplinare-sez. Nanoscienze, Università del Salento, Via Arnesano 16, Lecce I-73100, Italy
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  • Laura Blasi,

    1. National Nanotechnology Laboratories of CNR-INFM, Via Arnesano 16, Lecce I-73100, Italy
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  • Giuseppe Ciccarella,

    Corresponding author
    1. National Nanotechnology Laboratories of CNR-INFM, Via Arnesano 16, Lecce I-73100, Italy
    2. Dipartimento di Ingegneria dell'Innovazione, Università del Salento, Via Monteroni, Lecce I-73100, Italy
    • National Nanotechnology Laboratories of CNR-INFM, Via Arnesano 16, Lecce I-73100, Italy
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  • Giovanna Barbarella,

    1. CNR, Area di Ricerca, ISOF, Bologna I-40129, Italy
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  • Roberto Cingolani,

    1. National Nanotechnology Laboratories of CNR-INFM, Via Arnesano 16, Lecce I-73100, Italy
    2. Dipartimento di Ingegneria dell'Innovazione, Università del Salento, Via Monteroni, Lecce I-73100, Italy
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  • Giuseppe Gigli

    1. National Nanotechnology Laboratories of CNR-INFM, Via Arnesano 16, Lecce I-73100, Italy
    2. Dipartimento di Ingegneria dell'Innovazione, Università del Salento, Via Monteroni, Lecce I-73100, Italy
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Abstract

Nanometer-sized poly(acrylic acid) (PAA) hydrogels were synthesized by emulsion polymerization of methyl acrylate and subsequent acidic hydrolysis. The nanohydrogel was characterized by spectroscopic methods (FTIR and 1H-NMR) and scanning probe techniques, and their pH-dependent swelling behavior was studied by dynamic light scattering. To determine the suitability of PAA nanogels as pH-sensitive carriers for biomedical applications, uptake and release of an oligothiophene fluorophore and its albumin conjugated from PAA nanogels were investigated as a function of pH by absorption and photoluminescence measurements. It was observed that uptake and release processes of both the oligothiophene and its conjugate could be controlled by changing the pH of the external solution. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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