Reduction of postsurgical adhesion formation with CM-chitosan hydrogel barriers prepared by using γ-irradiation

Authors

  • Hui-Jeong Gwon,

    1. Radiation Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeonbuk 580-185, Korea
    2. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejon 305-701, Republic of Korea
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  • Youn-Mook Lim,

    1. Radiation Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeonbuk 580-185, Korea
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  • Ho-Nam Chang,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejon 305-701, Republic of Korea
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  • Young-Chang Nho

    Corresponding author
    1. Radiation Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeonbuk 580-185, Korea
    • Radiation Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeonbuk 580-185, Korea
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    •  Y.-C. Nho is a major contributor for this work.


Abstract

To evaluate the efficiency of carboxymethylchitosan (CM-chitosan)-based hydrogels as barriers for reducing postsurgical adhesions, CM-chitosan was synthesized to simplify the hydrogel-making process, and the CM-chitosan solutions were cross-linked by using γ-ray irradiation to create the desired hydrogels instead of using chemical cross-linking reagents. The prepared CM-chitosan hydrogels were characterized by a FTIR spectroscopy, swelling behavior, gel-fraction content,and mechanical property such as gel strength of a hydrogel and the results showed a good swelling behavior and mechanical properties. Also, the radiation-induced CM-chitosan hydrogels significantly reduced and inhibited the postsurgical adhesions in the rat models. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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