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Synthesis and evaluation of a star amphiphilic block copolymer from poly(ε-caprolactone) and poly(ethylene oxide) as load and release carriers for guest molecules

Authors

  • Guohua Jiang,

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    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China
    2. Department of Materials Engineering, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China
    • Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Zhejiang Sci-Tech University, Ministry of Education, Hangzhou 310018, People's Republic of China
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  • Hao Xu

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China
    2. Department of Materials Engineering, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China
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Abstract

The use of polymeric materials as the carrier in the controlled release of guest molecules has become an important research area in the polymeric materials science, because of their advantages of the safety, efficacy and patient convenience. One of them, star amphiphilic polymer can self-assemble into supermolecular structure (polymer micelles) by the balance of hydrophilic and hydrophobic interaction. In this study, star amphiphilic copolymer consisting of hydrophobic and biodegradable poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO) blocks were synthesized by two-step ring-opening polymerization. The resultant polymer was characterizated by FTIR, 1H-NMR, and DSC to determine its chemical structure. The morpholoy of the polymer micelles was analyzed by TEM. Using star-PCL-b-PEO as carriers and congo red as model guest molecules, the encapsulation and release properties were investigated by UV–visable analysis. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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