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Synthesis, characterization, and biodegradation of maleic anhydride, ethylene glycol-copolymerization modified poly(D,L-lactide acid) and their crosslinked products

Authors

  • Meina Huang,

    Corresponding author
    1. Key Laboratory of Biorheological Science and Technology, Bioengineering College, Chongqing University, Ministry of Education, China
    2. National 985 Research Center of Bioinspired Material Science and Engineering, Bioengineering College, Chongqing University, Ministry of Education, China
    • Key Laboratory of Biorheological Science and Technology, Bioengineering College, Chongqing University, Ministry of Education, China
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  • Yuanliang Wang,

    1. Key Laboratory of Biorheological Science and Technology, Bioengineering College, Chongqing University, Ministry of Education, China
    2. National 985 Research Center of Bioinspired Material Science and Engineering, Bioengineering College, Chongqing University, Ministry of Education, China
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  • Yanfeng Luo

    1. Key Laboratory of Biorheological Science and Technology, Bioengineering College, Chongqing University, Ministry of Education, China
    2. National 985 Research Center of Bioinspired Material Science and Engineering, Bioengineering College, Chongqing University, Ministry of Education, China
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Abstract

Novel maleic anhydride (MAH), ethylene glycol oligomer-modified poly(D,L-lactide acid) (PEMLA), and crosslinked-PEMLA were synthesized via a series of chemical bulk modification. Briefly, MAH copolymerized with ethylene oligomer [EGO (including EG, PEG200, PEG400)] to give the PEMA; thereafter, D,L-lactide (DLLA) and prepolymers (PEMA) copolymerized to produce the PEMLA; at last, the crosslinked-PEMLA was synthesized by free radical reaction of the PEMLA. The characterization of PEMLA and crosslinked-PEMLA showed that the introduction of hydrophilic group [BOND]O[BOND] and [BOND]CH[DOUBLE BOND]CH[BOND] increased the flexibility and hydrophilicity of PDLLA. Moreover, the degradation of PEMLA and crosslinked-PEMLA were determined by molar weight changes and weight loss rate, and a special method, analysis of degradation positions via 1H-NMR, which indicated that the PEMLA and crosslinked-PEMLA have nice degradation, and the change of content of MAH, EGO can regulate the degradation rate of PDLLA. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

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