Terminal-specific PEGylation of polypeptides in a dilute solution

Authors

  • Jun Jim Wu,

    1. Defence Research and Development Canada–Toronto, Individual Readiness Section, Toronto, M3M 3B9 ON, Canada
    Current affiliation:
    1. Champion Technologies Inc., 3130 FM 521, Fresno, Texas 77545, USA
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  • Henry T. Peng,

    Corresponding author
    1. Defence Research and Development Canada–Toronto, Individual Readiness Section, Toronto, M3M 3B9 ON, Canada
    • Defence Research and Development Canada–Toronto, Toronto, M3M 3B9 ON, Canada
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  • Pang N. Shek

    Corresponding author
    1. Defence Research and Development Canada–Toronto, Individual Readiness Section, Toronto, M3M 3B9 ON, Canada
    • Defence Research and Development Canada–Toronto, Toronto, M3M 3B9 ON, Canada
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Abstract

PEGylations of polypeptides with a four-arm PEG (polyethylene glycol) in a dilute DMSO solution resulted in a successful conjugation with terminal specificity, which supports an intriguing PEGylation mechanism via conformational and kinetic control. © 2010 Crown in the right of Canada. J Appl Polym Sci, 2010

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