Crosslinking of electrospun fibrous gelatin scaffolds for apatite mineralization

Authors

  • Jin Zhao,

    Corresponding author
    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    • Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    Search for more papers by this author
  • Yuping Zhao,

    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    Search for more papers by this author
  • Qianqian Guan,

    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    Search for more papers by this author
  • Gongwen Tang,

    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    Search for more papers by this author
  • Yunhui Zhao,

    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    Search for more papers by this author
  • Xiaoyan Yuan,

    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    Search for more papers by this author
  • Kangde Yao

    1. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin Univeristy, Tianjin 300072, China
    2. Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China
    Search for more papers by this author

Abstract

Fibrous gelatin scaffolds fabricated via electrospinning followed by crosslinking were used as substrates for apatite mineralization. Gelatin macromolecules were confined by their fibers and further restricted by the crosslinked structure while proper flexibility could be attained upon hydration. After 4 or 5 days of mineralization, partially carbonated hydroxyapatite was proved to deposit uniformly on the surface of the fibers. The property of the substrate, such as stiffness of the scaffolds and flexibility of macromolecules chain, was changed by different crosslinking ways. The influences of these properties on the formation of apatite were also investigated. Results showed that a relatively less rigid interface and more flexible chain acquired by glutaraldehyde solution crosslinking seemed to favor the nucleation of minerals and to reduce the size of the inorganic products. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

Ancillary