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Synthesis and characterization of novel lipid functionalized poly(ε-caprolactone)s

Authors

  • E. Oledzka,

    1. Trent University Biomaterials Research Program, Department of Physics and Astronomy, Trent University, Peterborough, Ontario, K9J 7B8, Canada
    2. Trent University Biomaterials Research Program, Department of Chemistry, Trent University, Peterborough, Ontario, K9J 7B8, Canada
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  • X. Kong,

    1. Department of Agricultural Food and Nutritional Science, 4-10 Agriculture/Forestry Centre, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
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  • S. S. Narine

    Corresponding author
    1. Trent University Biomaterials Research Program, Department of Physics and Astronomy, Trent University, Peterborough, Ontario, K9J 7B8, Canada
    2. Trent University Biomaterials Research Program, Department of Chemistry, Trent University, Peterborough, Ontario, K9J 7B8, Canada
    • Trent University Biomaterials Research Program, Department of Physics and Astronomy, Trent University, Peterborough, Ontario, K9J 7B8, Canada
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Abstract

A series of novel lipid functionalized poly(ε-caprolactone)s (PCLs) were synthesized through ROP of ε-caprolactone in the presence of threo-9,10-dihydroxyoctadecanoic acid, synthesized from oleic acid. PCLs with different molecular weights were obtained by controlling the molar ratio of the initiator to the monomer. DSC and XRD analysis indicate that the crystallinity of PCLs decreased when compared to unfunctionalized PCL. The enzymatic degradation study shows that for samples with lower lipid derivatives content, a higher enzymatic degradation rate was observed because the lipase enzymes attack the ester bonds of the polymer; increased lipid content therefore inhibits the action of the lipase enzymes. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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