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Efficiency and biocompatibility of antimicrobial textile material of broad spectrum activity

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Abstract

The subject of this article is to study the behavior of the antimicrobial textile material. The material is in the form of plaster wound dressing which is consisting of a nonwoven textile base containing polypropylene (PP)/viscose, a polymer carrier, and an antimicrobial active substance. The polymer carrier is the polysaccharide D-glucosamine (chitosan), and the active antimicrobial substance is antibiotic gentamicin sulfate. The amount of gentamicin sulfate immobilized into the polymer matrix of the polymer carrier was 0.15–0.20 mg/cm2 or 2.0–2.5% of the mass of the nonwoven textile material. The antimicrobial textile material has been studied in vitro and in vivo conditions through the efficiency of the antimicrobial effects on different kinds of pathogenic microorganisms, as well as the biocompatibility in preclinical research. The results of these experiments indicate that all bioactive textile materials were biocidal in vitro for all pathogenic test organisms. Good biocompatibility, the existence of the correlation between the in vitro and in vivo results, concerning efficiency, qualifies these antimicrobial biomaterials for clinical use. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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