Surface characteristics of poly(γ-alkyl α l-glutamate)s with different alkyl groups

Authors

  • Lin-Jun Shao,

    1. Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China
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  • Jian Wu,

    1. Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China
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  • Zhen-Mei Liu,

    1. Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science & Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
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  • Zhi-Kang Xu

    Corresponding author
    1. Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science & Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
    • Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China
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Abstract

A series of poly(γ-alkyl α L-glutamate)s with different alkyl groups were synthesized by the ring opening polymerization of corresponding α-amino acid N-carboxyanhydrides. The characteristics of these polyglutamate surfaces were evaluated by attenuated total reflectance Fourier transform infrared spectroscopy spectra, water contact angle, water absorption, protein adsorption, and platelet adhesion measurements. Changing the length of the alkyl side chain provides a unique opportunity to study the influence of carbon number in the alkyl group on the surface properties of the polyglutamates. Water contact angle and water absorption data show that the hydrophilicity of these polyglutamate surfaces decreases with the increasing of methylene in the alkyl group. Protein adsorption on these polyglutamate surfaces increases with the enhancing of surface hydrophobicity. However, the changes in platelets adhesion could be attributed to the hydrophilicity/hydrophobicity of the polyglutamates and the specific effect of alkyl group. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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