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Synthesis and antimicrobial activity of some cross-linked copolymers with alkyl chains of various lengths

Authors

  • Yuhong Zhang,

    1. Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China
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  • Xiaohong Li,

    1. Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China
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  • Qinzheng Dong,

    1. Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China
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  • Peixin He

    Corresponding author
    1. Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China
    • Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People's Republic of China
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Abstract

Amphoteric polymer hydrogels were prepared by the copolymerization of three kinds of N,N′-dimethyl-N-alkylmethacryloxylethyl ammoniumbromide (DMAEA) with different lengths of alkyl chains (DMAEA-RB) (R-ehtyl/hexyl/dodecyl), acrylic acid (AA), and acrylamide (AM). The water content of the AA-AM-(DMAEA-RB) terpolymers decreased with the increasing length of alkyl chains in quaternary ammonium group in the terpolymers and increased with the increasing molar ratio of DMAEA-RB to 2 mol % and then decreased. Their antibacterial activities against Escherichia coli and Staphylococcus hyicus were investigated by a colony count method. It was found that the copolymer exhibited higher antibacterial activity with increasing chain length of alkyl groups in ammonium groups. For P[AA-AM-(DMAEA-DB)], the DMAEA-DB content is higher and contact time is longer, its antibacterial activity is better. However, when the contact time and quaternary ammonium content were above 30 min and 2%, respectively, the amount of live cells N(t) in a cell suspension increased in the presence of P[AA-AM-(DMAEA-EB)] or P[AA-AM-(DMAEA-HB)]. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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