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Diffusion of levofloxacin mesylate in agarose hydrogels monitored by a refractive-index method

Authors

  • Hongjun Dai,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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  • Junjie Wu,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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  • Yongxin Wang,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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  • Shuaixia Tan,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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  • Songmiao Liang,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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  • Bin Jiang,

    1. Second People's Hospital of Baoding, Hebei 032100, People's Republic of China
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  • Ning Zhao,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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  • Jian Xu

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
    • Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China
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Abstract

The diffusion of levofloxacin mesylate (MSALVFX) within agarose hydrogels was investigated by an improved refractive-index method. The diffusion coefficient of MSALVFX in infinite dilution (D0) was obtained as 4.01 × 10−6 cm2/s (25°C) through extrapolation according to Kohlrausch's law. The diffusion behavior of MSALVFX under conditions of different solute concentrations, polymer volume fractions, and temperatures was studied in detail. In the considered range of agarose concentrations (0.5–2.5%, w/w), the ratio of Dg to D0 (where Dg is the effective diffusion coefficient of MSALVFX in the agarose hydrogel) decreased from 0.938 to 0.835 because of the retardance effect of agarose fiber. Furthermore, the experimental data were analyzed with the Amsden, Clague and Philips, and Ogston models, and the data fit the Amsden model best. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

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