A new method for the preparation of gelatin nanoparticles: Encapsulation and drug release characteristics

Authors

  • B. Vijaya Kumar Naidu,

    1. Department of Material Science and Nanotechnology, Yogi Vemana University, Kadapa 516 003, Andhra Pradesh, India
    2. Department of Process Engineering and Applied Science, Dalhousie University, Halifax, NS, Canada, B3J 2X4
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  • Allan T. Paulson

    Corresponding author
    1. Department of Process Engineering and Applied Science, Dalhousie University, Halifax, NS, Canada, B3J 2X4
    • Department of Process Engineering and Applied Science, Dalhousie University, Halifax, NS, Canada, B3J 2X4===

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Abstract

A new and simple method was developed to produce gelatin nanoparticles of ∼ 30–40 nm for use as carriers for drug release applications. The nanoparticles were uniform in size and well dispersed. An anticancer drug, 5-fluorouracil, was encapsulated with an efficiency as high as 85%. The nanoparticles showed sustained release of 5-fluorouracil, and release rates varied with amount of crosslinking in the nanoparticles. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011.

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