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Synthesis of hyperbranched polycarbosilane modified with cyclodextrin derivatives and its application in coated capillary electrophoresis columns



A series of hyperbranched polycarbosilanes were synthesized and coated on the inner surface of fused-silica capillaries by chemical bonding. The end groups of the hyperbranched polycarbosilanes were modified with β-cyclodextrin derivatives. The chiral isomers of ofloxacin and chlorpheniramine were separated by this new type of chiral capillary electrophoresis column and high-column efficiency was achieved. The results showed that ofloxacin was completely separated at pH 3.0; the separation resolution was 2.32, and theoretical plates were greater than 4.5 × 104 plates m−1. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011.

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