Electrospun fibers from functional polyglycidol/poly(ε-caprolactone) blends with defined surface properties

Authors

  • D. Haamann,

    1. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
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  • M. Bispinghoff,

    1. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
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  • D. Hönders,

    1. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
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  • C. Suschek,

    1. Department of Plastic Surgery, Hand and Burns Surgery, University Hospital Aachen, 52074 Aachen, Germany
    2. Department of Trauma and Hand Surgery, University Hospital Düsseldorf, 40225 Düsseldorf, Germany
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  • M. Möller,

    Corresponding author
    1. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
    • Institute of Technical and Macromolecular Chemistry, RWTH Aachen and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
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  • D. Klee

    Corresponding author
    1. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
    • Institute of Technical and Macromolecular Chemistry, RWTH Aachen and DWI an der RWTH Aachen e.V., 52056 Aachen, Germany
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Abstract

Highly hydrophilic but water insoluble fibers from star-shaped poly(ethoxyethyl glycidyl ether) and poly(ε-caprolactone) polymer blends in the submicron range were prepared using the electrospinning technique. The fibers were achieved in a smooth and homogeneous manner and do show tremendous decreased protein adsorption. Additionally, using alkyne- or vinyl sulfonate end capped polymer, fibers with the correspondent surface reactivity have been prepared. All fibers showed high biocompatibility and were highly hydrophilic but water stable. Furthermore, nonwovens based on functionalized poly(ethoxyethyl glycidyl ether) were equipped with small biofunctional molecules, e.g., the peptide sequence glycine-arginine-glycine-aspartate-serine (GRGDS). These fibers showed increased cell attachment compared with nonfunctionalized nonwovens. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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