Amphiphilic dextran derivatives nanoparticles for the delivery of mitoxantrone

  1. Huan Wang1,2,
  2. Siyuan Han1,2,
  3. Jihong Sun2,*,
  4. Tengfei Fan1,
  5. Cixia Tian1,
  6. Yan Wu1,*

Article first published online: 10 FEB 2012

DOI: 10.1002/app.36534

Additional Information

How to Cite

Wang, H., Han, S., Sun, J., Fan, T., Tian, C. and Wu, Y. (2012), Amphiphilic dextran derivatives nanoparticles for the delivery of mitoxantrone. J. Appl. Polym. Sci.. doi: 10.1002/app.36534

Author Information

  1. 1

    National Center for Nanoscience and Technology, Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, Beijing, China, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China

  2. 2

    College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China

*College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China

Publication History

  1. Article first published online: 10 FEB 2012
  2. Manuscript Accepted: 11 NOV 2011
  3. Manuscript Received: 14 NOV 2010

Funded by

  • State Key Development Program for Basic Research of China (973). Grant Numbers: 2009CB930200, 2010CB934004, (863) 2007AA02Z150

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Keywords:

  • copolymers;
  • drug delivery systems;
  • nanoparticle

Abstract

In this work, biodegradable amphiphilic copolymer nanoparticles based on dextran, polylactide (PLA), and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) were prepared. To estimate their feasibility as drug carriers, an antitumor model drug, mitoxantrone (MTO), was successfully incorporated into the polymeric nanoparticles by double-emulsion (DE) and nanoprecipitation (NP) methods. The MTO-loaded nanoparticles were confirmed by dynamic light scattering and transmission electron microscopy. The MTO-loaded nanoparticle size, size distribution, and encapsulation efficiency were influenced by the feed weight ratio of the copolymer to MTO. In addition, in vitro release experiments showed that the release behavior was affected by the fabrication method and the pH of the release media. The MTO-loaded nanoparticles showed faster release by the NP method and at pH 5.4 than by the DE method and in pH 7.4 buffer. The dextran–PLA–DPPE polymeric nanoparticles could be useful as drug carriers for antitumor drug delivery. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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