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Fabrication of patterned PDLLA/PCL composite scaffold by electrospinning

Authors

  • He Xu,

    1. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
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  • Wenguo Cui,

    1. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
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  • Jiang Chang

    Corresponding author
    1. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
    2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China
    • School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China
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Abstract

Fabricating fibrous electrospun scaffolds with controllable fiber-arrangement have gained an increasing attention in the field of tissue engineering. In this study, the composite patterned D,L-poly(lactic acid)/poly(ε-caprolactone) (PDLLA/PCL) scaffolds were fabricated via electrospinning for the first time, and the order degree and contractibility of patterned composite scaffolds with different PDLLA/PCL ratios were further investigated. The results showed that the order degree of the pattern and in vitro shrinkage behaviors of PDLLA/PCL electrospun mats could be finely tuned by controlling blending ratios. The PDLLA/PCL electrospun mats with the ratio 50/50 showed the most balanced properties with controllable pattern structure and appropriate dimensional stability, and they might be a suitable candidate for tissue engineering application. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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