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Scaffolds based on hydroxypropyl starch: Processing, morphology, characterization, and biological behavior

Authors

  • Itziar Silva,

    1. Institute of Polymer Science and Technology, CSIC, C/Juan de la Cierva 3, Madrid 28006, Spain
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  • Mariló Gurruchaga,

    Corresponding author
    1. Department of Polymer Science and Technology, POLYMAT (Institute of Polymeric Materials), University of The Basque Country (UPV/EHU), San Sebastian 20080, Spain
    • Department of Polymer Science and Technology, POLYMAT (Institute of Polymeric Materials), University of The Basque Country (UPV/EHU), San Sebastian 20080, Spain
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  • Isabel Goñi,

    1. Department of Polymer Science and Technology, POLYMAT (Institute of Polymeric Materials), University of The Basque Country (UPV/EHU), San Sebastian 20080, Spain
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  • Mar Fernández-Gutiérrez,

    1. Institute of Polymer Science and Technology, CSIC, C/Juan de la Cierva 3, Madrid 28006, Spain
    2. CIBER-BBN, Ebro River Campus, Building R&D, Poeta Mariano Esquillor s/n, Zaragoza 50017, Spain
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  • Blanca Vázquez,

    1. Institute of Polymer Science and Technology, CSIC, C/Juan de la Cierva 3, Madrid 28006, Spain
    2. CIBER-BBN, Ebro River Campus, Building R&D, Poeta Mariano Esquillor s/n, Zaragoza 50017, Spain
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  • Julo San Román

    1. Institute of Polymer Science and Technology, CSIC, C/Juan de la Cierva 3, Madrid 28006, Spain
    2. CIBER-BBN, Ebro River Campus, Building R&D, Poeta Mariano Esquillor s/n, Zaragoza 50017, Spain
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Abstract

In this study, a novel electrospun hybrid scaffold was developed, which consists of a blend of a modified natural substance, hydroxypropyl starch (HPS) with a synthetic one, poly(ethylene oxide) (PEO). Nanofibers with varying polysaccharide contents were fabricated using water as solvent and the electrospinning process conditions investigated as a function of the weight ratio of the blend. The fibers were characterized through mean diameter and morphology by scanning electron microscopy. Micrographs clearly showed the effect of HPS/PEO weight ratio of the blend on the nanofibers formation. Stability of the fibers was enhanced by coating with hydrophobic poly(methyl methacrylate) (PMMA). In vitro degradation analysis of the coated mats after 1 month of immersion showed porous formation, whereas the fibrous structure was retained. The biological response of the mats against human fibroblasts proved that cells were able to adhere to and proliferate on the fibrous materials. Thus, the feasibility of producing nanofibers of HPS/PEO blends with high proportion of starch and their biocompatibility after coating with PMMA was demonstrated, indicating that these materials have potential to be used as scaffolds in tissue engineering applications. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci., 2013

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