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Syntheses, characterization, and antibacterial activity of chitosan grafted hydrogels and associated mica-containing nanocomposite hydrogels

Authors

  • Supaporn Noppakundilograt,

    1. Department of Printing and Imaging Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
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  • Kittichai Sonjaipanich,

    1. Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
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  • Nuttha Thongchul,

    1. Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok 10330, Thailand
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  • Suda Kiatkamjornwong

    Corresponding author
    1. Department of Printing and Imaging Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    2. Division of Science, the Royal Institute of Thailand, Sanam Seuba, Dusit 10300, Thailand
    • Department of Printing and Imaging Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
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Abstract

Chitosan (CS) grafted poly[(acrylic acid)-co-(2-hydroxyethyl methacrylate)] (CS-g-poly(AA-co-HEMA)) at different molar ratios of AA and HEMA, and the associated nanocomposite hydrogels of CS-g-poly(AA-co-HEMA)/mica were synthesized by radical copolymerization. The grafting positions at the amino or hydroxyl groups in the CS were identified by Fourier transform infrared spectroscopy. CS-g-poly(AA-co-HEMA) hydrogels were intercalated in the mica and the amount of hydrogel insertion did not affect the spacing of the silicate layers in mica. The higher mica loadings produced a rougher surface of the nanocomposite hydrogel. The water absorbency of the CS-g-poly(AA-co-HEMA)/mica nanocomposite hydrogels decreased with increasing levels of mica loading to a lower level than those of the CS-g-poly(AA-co-HEMA) hydrogels. Both CS-g-poly(AA) and CS-g-poly(AA-co-HEMA)/mica nanocomposite hydrogels exhibited a higher antiproliferative activity against Staphylococcus aureus than did the neat CS hydrogel with CS-g-poly(AA) revealing a very pronounced minimum inhibition concentration (MIC) of 1.56 mg mL−1. The extent of mica loading in the CS-g-poly(AA-co-HEMA) nanocomposite hydrogels did not affect the MIC (12.5 mg mL−1). © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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