Poly(ε-caprolactone) composites containing gentamicin-loaded β-tricalcium phosphate/gelatin microspheres as bone tissue supports

Authors

  • Umran Aydemir Sezer,

    1. BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, 06800 Ankara, Turkey
    2. Graduate Department of Biomedical Engineering, Middle East Technical University, 06800 Ankara, Turkey
    3. Department of Chemical Engineering and Applied Chemistry, Faculty of Engineering, Atilim University, 06836 Ankara, Turkey
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  • Eda Ayse Aksoy,

    1. BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, 06800 Ankara, Turkey
    2. Central Laboratory, Middle East Technical University, 06800 Ankara, Turkey
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  • Vasif Hasirci,

    1. BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, 06800 Ankara, Turkey
    2. Graduate Department of Biomedical Engineering, Middle East Technical University, 06800 Ankara, Turkey
    3. Department of Biological Sciences, Faculty of Arts and Sciences, Middle East Technical University, 06800 Ankara, Turkey
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  • Nesrin Hasirci

    Corresponding author
    1. BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, 06800 Ankara, Turkey
    2. Graduate Department of Biomedical Engineering, Middle East Technical University, 06800 Ankara, Turkey
    3. Department of Chemistry, Faculty of Arts and Sciences, Middle East Technical University, 06800 Ankara, Turkey
    • BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, 06800 Ankara, Turkey
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Abstract

In this work, novel antibacterial composites were prepared by using poly(ε-caprolactone) (PCL) as the main matrix material, and gentamicin-loaded microspheres composed of β-tricalcium phosphate (β-TCP) and gelatin. The purpose is to use this biodegradable material as a support for bone tissue. This composite system is expected to enhance bone regeneration by the presence of β-TCP and prevent a possible infection that might occur around the defected bone region by the release of gentamicin. The effects of the ratio of the β-TCP/gelatin microspheres on the morphological, mechanical, and degradation properties of composite films as well as in vitro antibiotic release and antibacterial activities against Escherichia coli and Staphylococcus aureus were investigated. The results showed that the composites of PCL and β-TCP/gelatin microspheres had antibacterial activities for both bacteria. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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