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In situ formation of biodegradable dextran-based hydrogel via Michael addition

Authors

  • Geng Peng,

    1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Jing Wang,

    Corresponding author
    1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    • State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Fan Yang,

    1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Shuo Zhang,

    1. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Juan Hou,

    1. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    2. Key Laboratory for Ultrafine Materials of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Wanli Xing,

    1. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Xun Lu,

    1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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  • Changsheng Liu

    Corresponding author
    1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    2. Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    3. Key Laboratory for Ultrafine Materials of Education, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
    • State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China
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Abstract

Vinyl-sulfone-functionalized dextran (Dex-VS) was readily prepared by a single-batch synthetic procedure at room temperature. The thiol molecule, 1,4-dithioerythritol (DTE, commercially available) with two terminal thiol groups was used as crosslinking agent. Hydrogels were rapidly prepared in situ by Michael addition under mild physiological conditions. Properties including gelation duration, mechanical modulus, and degradation behavior could be expediently controlled. Moreover, the hydrogels had comparatively low cytotoxicity, and the in vivo tests demonstrated an effective delivery of growth factor. This study might provide a powerful material to be used in tissue regeneration. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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